Clinical and Radiographic Evaluation of Revascularization of Immature Anterior Permanent Teeth Using (CGF) Versus (BC)
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 50
- 主要终点
- clinically successful treatment
研究概览
简要总结
The aim of this study is to compare clinical and radiographic evaluation treatment of necrotic immature permanent teeth using:
- Concentrated Growth Factor
- Blood Clot
详细描述
Rationale for conducting the research:
Concentrated growth factor (CGF) is relatively a new generation of platelet concentrate product, it contains more cytokines and growth factors compared with PRP and PRF also promotes the proliferation, migration, and differentiation of stem cells.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 8 Years 至 14 Years（Child）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Children aged between 8_14 years.
- •Anterior tooth diagnosed with necrotic pulp (due to trauma, caries, or anomaly) responded negatively to sensibility tests.
- •Teeth not indicated for post and core.
- •A cooperative and compliant patient/parent.
- •Patients not allergic to medicaments necessary to complete the procedure.
- •Patients with no history of chronic systemic diseases.
排除标准
- •Medically compromised patient.
- •Teeth with vertical fractures.
- •Non-restorable teeth.
- •Teeth when bleeding could not be induced.
- •Unable to attend follow-up visits.
研究组 & 干预措施
Concentrated Growth Factor (CGF)
Concentrated growth factor (CGF) is relatively a new generation of platelet concentrate product, it contains more cytokines and growth factors compared with PRP and PRF also promotes the proliferation, migration, and differentiation of stem cells
干预措施: concentrated growth factors in open apex (Procedure)
Concentrated Growth Factor (CGF)
Concentrated growth factor (CGF) is relatively a new generation of platelet concentrate product, it contains more cytokines and growth factors compared with PRP and PRF also promotes the proliferation, migration, and differentiation of stem cells
干预措施: Blood Clot (BC) (Procedure)
Blood Clot (BC)
Inducing bleeding to facilitate healing is a common surgical procedure. The blood clot formed after hemorrhage, acts as a scaffold and rich source of growth factors, and could play an important role in tissue repair in the canal. The growth factors could stimulate differentiation, growth, and maturation of fibroblasts, odontoblasts and cementoblasts, from the immature undifferentiated mesenchymal cells in the newly formed tissue matrix
干预措施: concentrated growth factors in open apex (Procedure)
Blood Clot (BC)
Inducing bleeding to facilitate healing is a common surgical procedure. The blood clot formed after hemorrhage, acts as a scaffold and rich source of growth factors, and could play an important role in tissue repair in the canal. The growth factors could stimulate differentiation, growth, and maturation of fibroblasts, odontoblasts and cementoblasts, from the immature undifferentiated mesenchymal cells in the newly formed tissue matrix
干预措施: Blood Clot (BC) (Procedure)
结局指标
主要结局
clinically successful treatment
时间窗: 3,6,9,12 months
The treatment will be considered to be clinically successful when. Absence of pain will record it by verbal question to patient/ parent. Absence of tenderness to percussion) will record it by percussion test (by the back of the dental mirror) Absence of swelling and fistula or sinus tract -- will record it by visual clinical examination
次要结局
- Radiographic Success treatment(6, 12 months)
研究者
Hana Ahmed Omer
PhD researcher in pediatric dentistry and public health department
Cairo University