Strengthening Strategies for Knee Osteoarthritis: A Randomized Trial of Eccentric vs. Isometric Exercise
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Pain (Numeric Pain Rating Scale), Pressure Pain Threshold (Algometer), Muscle strength (Sphygmomanometer), Range of Motion (Goniometer)
研究概览
简要总结
We plan to carry out a six-week randomized clinical trial. We will compare the effectiveness of eccentric and isometric exercises including a control group for participants with knee osteoarthritis. This study aims to determine the knee osteoarthritis-related sociodemographic characteristics, baseline comparison at the pretest, and determine the effectiveness of eccentric vs isometric exercise on pain, pressure pain threshold, muscle strength, range of motion, functional ability, and walking ability of knee osteoarthritis patients after completing interventions. There will be also a follow-up period of 24 weeks. We expect better treatment outcomes after 18 sessions of intervention for knee osteoarthritis participants who receive eccentric strengthening exercises along with conventional care.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Participant, Investigator, Outcome Assessor and Date-entry Operator Blinded
入排标准
- 年龄范围
- 45.00 Year(s) 至 70.00 Year(s)（—）
- 性别
- All
入选标准
- •Individuals will be included in this trial if (1) ages 45 – 70 for both men and women, (2) the presence of knee OA for at least six months following American College of Rheumatology criteria, (3) able to walk without the use of any aids and able to flex the knee beyond 90 degrees, (4) anterior-posterior bilateral standing radiograph presents Kellgren and Lawrence Grade II/III knee OA, and (5) absence any unusual cardiac response during the six-minute walk test.
排除标准
- •Individuals will be excluded if (1) knee surgery has been performed in the previous twelve months, (2) lumbar radiculopathy, vascular claudication, severe anterior-sided knee pain resulting from patella-femoral syndrome or chondromalacia, as well as further neurological, muscular, or joint conditions that could impair the function of the lower limbs, (3) visible malformation of the knee, either varus or valgus, (4) Received hyaluronic acid or corticosteroid injections within three months of study enrollment, (5) pregnancy, and (6) BMI over 30.
结局指标
主要结局
Pain (Numeric Pain Rating Scale), Pressure Pain Threshold (Algometer), Muscle strength (Sphygmomanometer), Range of Motion (Goniometer)
时间窗: At baseline, after 6 weeks and 24 weeks
次要结局
- Functional ability (WOMAC), Walking ability (6MWT)(10 months)
研究者
Kazi Md Azman Hossain
Jashore University of Science and Technology (JUST), Jashore