Fuwai Hospital, Chinese Academy of Medical Science
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 400
- 试验地点
- 1
- 主要终点
- postoperative new-onset atrial fibrillation
研究概览
简要总结
Surgical occlusion of the left atrial appendage (LAAO) is sometimes performed during the cardiac surgery to reduce long-term risk of stroke.A previous study found that LAAO may be associated with increased risk of postoperative atrial fibrillation.New-onset atrial fibrillation (NOAF) after coronary artery bypass graft is related to an increased short-term and long term risk of stroke and mortality.Marshall ligament amputation may reduce the occurence of atrial fibrillation. However, little is known whether this approach is justified during the coronary artery bypass graft.Therefore, this study aimed to investigate whether LAAO and Marshall ligament amputation during off-pump coronary artery bypass was associated with reduced risks of postoperative new-onset atrial fibrillation and stroke.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •isolated first off-pump coronary artery bypass
排除标准
- •Preoperative atrial fibrillation or a history of atrial fibrillation;
- •Concurrent cardiac or non-cardiac surgery
- •Intraoperative convert to bypass bypass surgery
- •Emergency surgery
- •History of previous cardiac surgery
- •Severe organ dysfunction
结局指标
主要结局
postoperative new-onset atrial fibrillation
时间窗: 7 days
Postoperative atrial fibrillation (POAF), defined as new-onset atrial fibrillation (AF) in the immediate period after surgery, is the most important type of secondary AF.
次要结局
- stroke(1 months,3 months, 1years, 3years, 5years.)