RDN-HT

Not Applicable

• Conditions: Resistant hypertension

• Registration Number: JPRN-jRCTs042180047
• Lead Sponsor: Takamura Masayuki

Brief Summary

We performed renal denervation in 5 patients with resistant hypertension.Average age was 61.6 years old, Office blood pressure was 173.6mmHg and 98.8mmHg, 24 hours ABPM was 151.8mmHg and 91.8mmHg. Average number of antihypertensive medication was 3.6. No severe adverse event occurred in our study. Avereage systolic blood pressure was reduced at 12 months after renal denervation (173.6to 155.8mmHg). Muscle sympathetic nerve activity at baseline was reduced after renal denervation (46 to 42.6burst/min).

Detailed Description

Not available

Study Timeline

• Results First Posted: 2015-07-01
• Study Completion: 2018-06-30
• Study Start: 2019-02-14
• Last Update Posted: 17 October 2023

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 5

Inclusion Criteria

Patients whose systolic pressure is beyond 160mmHg in spite of taking more than 3 kinds of antihypertensive drug(patients whose systolic pressure is beyond 150mmHg, if he is a diabetic)

Exclusion Criteria

1)Anatomical anomaly of renal artery inappropriate for the operation
2)Estimated glomerular filtration rate is less than 45mL/min
3)History of myocardial infarction, angina pectoris, or cerebrovascular accident within 6 month
4)Type1 diabetes mellitus
5)Secondary Hypertension

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1)Safety during perioperative period and chronic phase after the operation(evaluated with eGFR and imaging study) <br>2)Onset or progression of cardiovascular disease

Secondary Outcome Measures

Name	Time	Method
1)Safety of the technique in the operation <br>2)Systolic blood pressure one year after the operation <br>3)Sympathetic nerve activity after the operartion(evaluated with muscle sympathetic nerve activity and blood hormone such as catecholamine)