Effects of low-frequency magnetic fields on sleep and markers of Alzheimer's disease in humans
- Conditions
- Healthy volunteers
- Registration Number
- DRKS00029254
- Lead Sponsor
- Bundesamt für Strahlenschutz
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 40
• Current physical and mental health
• Postmenopausal women (last menstruation one year ago)
• No or stable internal medication
• Currently no sleep disorder according to the International Classification of Sleep Disorders (ICSD 3; American Academy of Sleep Medicine, AASM, 2014)
• Regular sleep-wake cycle (sleep diary)
• Right-handedness
• Non-smoker
• Use of hypnotics
• Excessive consumption of substances that affect the central nervous system (including caffeinated drinks, alcohol, drugs)
• Working on night shift (22:00 to 06:00)
• Electronic or electrically conductive implants
• Piercings or non-removable metal body jewelry
• scores above cut-off in the Montreal Cognitive Assessment (MoCa, Nasreddine et al., 2005)
• scores above cut-off ??in screening questionnaires on sleep and health
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The primary endpoints are the sleep macrostructure and the objective sleep efficiency, as well as the Alzheimer-associated biomarkers Aß40/42 and tau proteins. The sleep parameters are recorded every night in the sleep laboratory (one night per exposure condition), the biomarkers are determined by taking a blood sample before and after every sleep recording in the sleep laboratory.
- Secondary Outcome Measures
Name Time Method The secondary endpoints are memory performance in the declarative and procedural memory test as well as the parameters for the subjective sleep quality derived from the evening-morning protocol and possible physical symptoms. These endpoints are also collected before and after each sleep recording in the sleep laboratory.