The effect of air or enriched air nitrox breathing during simulated diving on intravascular bubble formation following decompressio

Not Applicable

Completed

• Conditions: Decompression illness in hyperbaric medicine; Injury, Occupational Diseases, Poisoning; Caisson disease [decompression sickness]

• Registration Number: ISRCTN31681480
• Lead Sponsor: Centre Hospitalier Universitaire d'Angers (France)

Brief Summary

2016 Results article in http://www.ncbi.nlm.nih.gov/pubmed/27163253 results

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2007-08-10
• Study Start: 2016-03-25
• Last Update Posted: 8 May 2023

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 12

Inclusion Criteria

1. Forty-seven human volunteers
2. Age >18 years
3. Diving experience as confirmed by possession of a French recreational diver license
4. Absence of contraindication to dive

Exclusion Criteria

1. History of decompression accident(s)
2. Oxygen administration or diving within 24 hours before simulated dive
3. Absent or low intravascular bubble production (Bubble score = 1) after initial simulated test dive

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Pulsed Doppler measurements of the trunk of the pulmonary artery in order to quantify intravascular bubble formation. Measurements of at least 1 minute duration were performed by a certified cardiologist, blinded for the FiO2 at 0, 30, 60 and 90 minutes after decompression. Images were recorded and analyzed for bubble scores offline. A modified bubble score was used, based on the Doppler score system of Spencer. Bubbles scores were analyzed independently by two blinded reviewers.

Secondary Outcome Measures

Name	Time	Method
Decompression incidents by questionnaire 90 minutes after completion of the simulated dive.