Clinical Outcome and Cost-effectiveness of Reduced Noradrenaline by Using a Lower Blood Pressure Target in Patients with Cardiogenic Shock from Acute Myocardial Infarction: A Multicenter Randomized Trial

Phase 4

Recruiting

• Conditions: Cardiogenic shock; heart attack; 10011082

• Registration Number: NL-OMON56427
• Lead Sponsor: Cardiologie

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 776

Inclusion Criteria

'Planned early revascularization'
'Systolic blood pressure <90mmHg for > 30minutes, OR use of drugs to maintain
SBP>90 mmHg at presentation before randomization'
'Signs of pulmonary congestion'
'4. Signs of impaired organ perfusion with at least one of the following
criteria:
a) Altered mental status
b) Cold, clammy skin and extremities
c) Oliguria with urine output <30ml/hour
d) Serum lactate >2.0 mmol/L'

Exclusion Criteria

'Resuscitation >30 minutes'
'No intrinsic heart action'
'Cerebral deficit with fixed dilated pupils (not drug-induced)'
'Mechanical cause of cardiogenic shock'
'Onset of shock >12 hours'
'Massive lung embolism'
'Shock due to other cause (bradycardia, sepsis, hypovolemia, etc.)'

Study & Design

• Study Type: Interventional
• Study Design: Not specified