Investigation of Brain Mechanisms Involved in the Urinary Continence Mechanism Associated With Aging
概览
- 阶段
- 不适用
- 干预措施
- Brain functional MRI with simplified urodynamics
- 疾病 / 适应症
- Urgency Urinary Incontinence
- 发起方
- University of Pittsburgh
- 入组人数
- 207
- 试验地点
- 1
- 主要终点
- BOLD (Blood oxygen level dependent) fMRI signal contrast
- 状态
- 已完成
- 最后更新
- 昨天
概览
简要总结
Urge urinary incontinence (UUI) is a common problem in older people which vastly reduces quality of life, yet the cause and mechanism of disease are not well understood. This study will characterize brain control of the bladder in young and old continent individuals and age-matched incontinent counterparts. This will expand the investigators current knowledge of how the brain controls the bladder, how that control changes with age and disease, and suggest new targets to guide development of better treatment.
详细描述
Current data suggest that bladder control comprises 3 cerebral circuits that maintain continence by suppressing the voiding reflex in the midbrain. In the UUI phenotype that responded to BFB (Biofeedback assisted pelvic floor muscle therapy), the mechanism involved enhancing deactivation of the first brain circuit (medial prefrontal cortex, mPFC) which resulted in less activation of the second circuit (which includes the midcingulate cortex). In the phenotype that was resistant to BFB, no brain changes were seen. Although the investigators have an emerging picture of the brain's role in UUI, the investigators have only rudimentary understanding of what is 'normal', i.e. how the brain normally controls the bladder. Moreover, the investigators do not know whether this control mechanism is the same across the lifespan, or whether it changes owing to the impact of aging. Thus, the investigators aims are to characterize the brain's normal role in bladder control in both young and old people, to determine the changes in brain structure and function that lead to bladder control failure (UUI), and to examine how such changes differ between young and old individuals. To address the aims, the investigators will utilize detailed neuroimaging to evaluate 80 asymptomatic women and 80 women with UUI, each group divided into young (18-45) and old (65+ years) individuals. The study will enable the investigators to define the brain's key structures, functional activity, and mechanisms involved in normal bladder control, and to identify the differences in these elements among those with UUI, both young and old. By elucidating the mechanisms that mediate the brain's control (and loss of control) of bladder function, the proposed study should enhance the investigators working model, deepen the understanding of the impact of aging, and identify better targets for the treatment of UUI. It may thereby enable scientists to develop novel and more effective new therapies based on the revolution in neuroscience-and more hope for UUI sufferers.
研究者
Becky Clarkson
Research Assistant Professor of Medicine
University of Pittsburgh
入排标准
入选标准
- •'Old' (community-dwelling, mentally and functionally intact ambulatory women aged 65+ years) or 'Young' (equivalent women aged 18-45)
- •'Wet' (those who meet the International Continence Society definition of urgency urinary incontinence (urinary leakage accompanied by a sudden, strong urge to void which is difficult to defer) \>5 times per week, for 3 months despite treatment for reversible causes (e.g., Urinary tract infection) and confirmed by a mean of one episode per day of UUI on 3-day bladder diary) or 'Dry' (women without current or past UUI or other lower urinary tract symptoms.) Infrequent stress incontinence of a small amount is acceptable.
- •Urge-predominant mixed incontinence is acceptable provided the subject is able to differentiate between stress incontinence (SUI - leakage that coincides instantaneously with cough, laugh, exercise) and urgency incontinence, i.e., leakage accompanied by a sudden strong urge to void that is difficult to defer.
- •Those with current or previous use of anticholinergic/beta-3 agonist medications will be considered for the study if they are willing to go through a washout period of at least 4 weeks of duration.
排除标准
- •Current or prior treatment for UUI
- •Leakage on bladder diary not ascribed to minimal SUI (see bullet above)
- •All Groups: 'Wet' or 'Dry'; 'Young' or 'Old'
- •Cognitive impairment:
- •inability to perform a voiding diary/pad test
- •inability to reliably take daily medication
- •inability to comply with fMRI testing
- •Impaired mobility
- •o Timed up and go test ≥ 12 secs
- •Medical instability:
研究组 & 干预措施
Brain functional MRI with simplified urodynamics
Females with urgency urinary incontinence
干预措施: Brain functional MRI with simplified urodynamics
结局指标
主要结局
BOLD (Blood oxygen level dependent) fMRI signal contrast
时间窗: 20 minutes of a 1 hour MRI scan
BOLD signal contrast - voxel-wise subtraction of normalized brain activity signal measure (BOLD response) during bladder fluid withdrawal from that during bladder infusion. Magnitude of BOLD contrast is then compared using ANOVA to compare the four groups (old dry/old wet/young dry/young wet). Differences are displayed as a map of t-values for each voxel of the brain, showing likelihood of statistical significance of differences. A priori regions of interest i.e. the bed nucleus of the stria terminalis (BST), pontine micturition center (PMC), periaqueductal grey (PAG), insula, medial prefrontal cortex (mPFC), dorsal anterior cingulate cortex/supplementary motor area (dACC/SMA) will be specified. Since BOLD signal represents the normalized contrast in fMRI signal between two states as a proxy for cerebral blood flow, it does not have a unit.
次要结局
- Differences in white matter damage of brain structures(10 minutes of 1 hour MRI scan)
- Functional connectivity during infusion/withdrawal task(20 minutes of 1 hour MRI scan)
- Resting state analysis(10 minutes of 1 hour MRI scan)
- Differences in volume of brain structures(10 minutes of 1 hour MRI scan)
- Changes in brain structural integrity(15 minutes of 1 hour MRI scan)