JPRN-UMIN000016094已完成1 期
A phase I study of alternate-day administration of S-1 plus leucovorin with bevacizumab in patients with refractory metastatic colorectal cancer. - A phase I study of alternate-day administration of S-1 plus leucovorin with bevacizumab in patients with refractory metastatic colorectal cancer.
Aichi Cancer Center Hospital0 个研究点目标入组 16 人开始时间: 2014年12月31日最近更新:
适应症
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 发起方
- 入组人数
- 16
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 20years-old 至 ot applicable（—）
- 性别
- All
入选标准
- 未提供
排除标准
- •(1) Active multiple malignancy (2) History of severe drug-induced hypersensitivity (3) Symptomatic brain metastasis (4) Active infection (5) Interstitial pneumonia or pulmonary fibrosis (6) Serious complications (renal failure, liver failure, severe cardiac disease, uncontrolled diabetes, uncontrolled hypertension, ileus). (7) massive pleural or abdominal effusion (8) Diarrhea (9) Administration of phenytoin or flucytosine (10) Systemic administration of steroid (11) Thromboembolism (grade 3 or higher), myocardial infarction, brain infarction, or pulmonary embolism within 6 months before enrollment (12) Any major surgery or open biopsy within 4 weeks before enrollment (13) Systemaic administration of antiplatelet drugs or NSAIDs (14) Bleeding diathesis, coagulopathy or administration of anticoagulation (15) Active peptic ulcer (16) History of gastrointestinal perforation within 1 year before enrollment (17) Clinically significant mental disorder (18) Positive for HBs antigen (19) Women who are pregnant or patients who are unwilling to avoid pregnancy (20) Patients who are inappropriate for the study in the opinion of the investigator
研究者
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