Preoperative Metabolomic Analysis of Primary Lung Cancer: A Translational Clinical Trial of the Brown Cancer Center
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 249
- 试验地点
- 1
- 主要终点
- metabolic profiles of cancerous vs. healthy lung tissue
研究概览
简要总结
The purpose of this study is to learn more about the metabolic properties of lung cancer cells.
详细描述
It has long been known that cancer cells absorb and break down substances in the body differently than healthy, non-cancer cells. This process of absorbing and breaking down substances is known as metabolism and is increased in cancer cells. Recent research suggests that this increased metabolic activity makes it easier for cancer cells to multiply. The objective of the study is to characterize the metabolism of glucose by lung tumors by serum metabolite analysis, using a variant of glucose (sugar) which makes up 1% of glucose in nature.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •patients with suspected, clinically diagnosed, or histologically diagnosed lung cancer. Occasionally, other cancers (including metastatic cancers to the lung) may be resected for the study as negative controls for NSCLC, as warranted by the particulars of the case.
- •patients must have general medical conditions to allow them to undergo surgical resection of their primary tumor
排除标准
- •history of diabetes for the experimental group (surgery + glucose); patients with a history of diabetes are allowed in the control group (surgery/no glucose)
- •known hepatitis C or HIV (AIDS)
- •Healthy Subjects (Group 3)
- •Inclusion Criteria:
- •at least 30 years of age
- •preferably be fasting for 12 hours (minimum 8 hours) prior to enrollment
- •Exclusion Criteria:
- •prior history of diagnosed lung cancer
- •known hepatitis C or HIV (AIDS)
结局指标
主要结局
metabolic profiles of cancerous vs. healthy lung tissue
时间窗: after 13-C-glucose infusion
次要结局
- metabolic markers in expired breath(during surgery)
- glycolytic metabolism in plasma(before and after 13-C-glucose infusion)
- metabolic markers in urine(collected during surgery)
- metabolic markers in serum(before and after 13-C-glucose infusion)
- metabolic markers in bronchoalveolar fluid(during diagnostic bronchoscopy or during surgery)
研究者
Donald Miller
Professor
University of Louisville