Deep brain stimulation for Parkinson's Disease: a feasibility study on anatomical, functional and diffusion-weighted MRI
Completed
- Conditions
- Parkinson's Disease10028037
- Registration Number
- NL-OMON32349
- Lead Sponsor
- Academisch Ziekenhuis Maastricht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 15
Inclusion Criteria
older than 18 years
no known neurological deficits
Exclusion Criteria
subject displays abnormalities (anatomically or due to artifacts) on MRI scan
metallic prosthesis, neurostimulator or pacemaker in subject's body
other contra indications for MRI
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The primary study parameters of this study are qualitative: the visibility of<br /><br>the STN on anatomical MRI, the visibility of fiber bundles and thus the STN<br /><br>connectivity as can be derived from diffusion-weighted MRI.<br /><br><br /><br>Quantitative measures are the MRI image quality, represented as signal-to-noise<br /><br>ratio and contrast-to-noise ratio of the STN. We can analyze the spatial and<br /><br>angular resolution of the diffusion-weighted data. Concerning the functional<br /><br>MRI, the activation in the STN and other brain areas can be quantified using<br /><br>SPM2 software.</p><br>
- Secondary Outcome Measures
Name Time Method <p>Not applicable.</p><br>