Tumor Microenvironment in Lung Adenocarcinoma
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 300
- 主要终点
- Overall survival
研究概览
简要总结
Cancer immunotherapy has the great potential to achieve long-term survival in patients with a solid malignancy. However, the beneficial effect of cancer immunotherapy is seen in only a minority of patients. Mounting evidence suggests that immunosuppressive features in the tumor microenvironment prevent an effective antitumor defense. The aim of the investigators is to comprehensively analyze the cytokine profile and the tumor immune infiltrate in the tumor microenvironment and to investigate its prognostic significance in patients with radically resected lung adenocarcinoma.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Lung adenocarcinoma
- •Tumor stage IB and II
- •With or without adjuvant therapy
- •Complete surgical resection (R0)
- •No distant metastasis at the time of surgery (M0)
排除标准
- •Second cancer within 5 years
结局指标
主要结局
Overall survival
时间窗: From date of surgery until the date of death from any cause assessed up to 100 months
Association of tumor microenvironment with overall survival
次要结局
- Recurrence-free survival(From date of surgery until the date of first documented progression or date of death from any cause, whichever came first, assessed up to 100 months)
研究者
Dr. med. Seyer Safi
PD Dr. Seyer Safi
University Hospital Heidelberg