Transcutaneous pO2, Transcutaneous pCO2 and Central Venous SO2 Variations to Define Fluid Responsiveness
Not Applicable
Completed
- Conditions
- Fluid ChallengeShockHypotensionFluid Responsiveness
- Interventions
- Other: fluid challenge
- Registration Number
- NCT01941472
- Lead Sponsor
- Peking Union Medical College Hospital
- Brief Summary
Fluid challenge is often carried out in critical ill patients. Its responsiveness usually requires invasive monitoring. To use non-invasive methods is very tempting. Investigators hypothesize that transcutaneous pO2,transcutaneous pCO2 and Central Venous SO2 variations provide feasible estimation on fluid responsiveness in critical ill patients.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
- 18 years and older ICU patients;
- Septic shock;
- Monitored with PICCO or Swan-Ganz catheter;
- The decision of fluid challenge made by the treating physician;
Exclusion Criteria
- Evidence of fluid overload;
- Pregnancy
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Septic shock fluid challenge Adult patients (at least 18 years of age) with refractory hypotension secondary to sepsis who, at the discretion of treating physicians, required fluid challenge in the presence of invasive hemodynamic monitoring. Refractory hypotension was defined as need of vasopressors to maintain systolic blood pressure (SBP) no less than 90 mmHg despite adequate fluid resuscitation.
- Primary Outcome Measures
Name Time Method Fluid Responsiveness Immediately after fluid challenge, average 5 minutes Increase in cardiac index ≥ 10% after fluid challenge
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
MICU of Peking Union Medical College Hospital
🇨🇳Peking, Beijing, China