Bisphenol Role in the Pathogenesis of PCOS

Completed

• Conditions: PCOS
• Interventions: Diagnostic Test: Measurement of Bisphenol in urine

• Registration Number: NCT03436108
• Lead Sponsor: Aljazeera Hospital

Brief Summary

Polycystic ovary syndrome (PCOS) is the most common and the most heterogeneous endocrine disorder in premenopausal women. Its prevalence is estimated from 5 to 10% depending on the diagnosis' criteria .

Apart from signs of hyperandrogenism such as acne, hirsutism and hair loss; women with PCOS usually present with menstrual irregularities and fertility problems ..

Detailed Description

Bisphenol A is formed from acetone and phenol, it is used in production of epoxy resin, polyster resins and polyvarbonate resins. Epoxy resins are used in plastics, adhesives, and structural composites .

Humans are at the end of the food chain, thus they are exposed to the highest doses of these compounds. EDs have been detected in human adipose tissue and biological fluids such as: serum, urine, milk and amniotic fluid .

Additionally, it has been proven that BPA can also directly stimulate androgen synthesis in the ovarian theca-interstitial cells. A correlation between increased serum testosterone levels observed in women with PCOS with serum BPA concentrations has also been found .

Study Timeline

• Study First Submitted: 2018-02-11
• Study First Submitted QC: 2018-02-11
• Study First Posted: 2018-02-19
• Study Start: 2019-02-10
• Primary Completion: 2019-12-01
• Study Completion: 2020-01-20
• Status Verified: 2022-01
• Last Update Submitted: 2022-01-02
• Last Update Posted: 2022-01-14

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 220

Inclusion Criteria

• Age group: 18-40
• Females
• Diagnosed a case of polycystic ovary syndrome

Exclusion Criteria

• • Female patients with other acute or chronic illness

  • Cardiovascular disease
  • Neoplasms
  • Current smoking, diabetes mellitus,
  • Renal impairment (serum creatinine 120 mol/liter), and hypertension (blood pressure 140/85 mm Hg).

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
PCOS group	Measurement of Bisphenol in urine	patients who have PCOS
control group	Measurement of Bisphenol in urine	patients who donnot have PCOS

Primary Outcome Measures

Name	Time	Method
the number of participants who will have high level of bisphenol in btheir blood	within 6 weeks

Trial Locations

Locations (1)

Algazeerah; 🇪🇬 Giza, Egypt