Role of Bisphenol A (BPA) in the Pathogenesis of the Polycystic Ovary Syndrome
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Aljazeera Hospital
- Enrollment
- 220
- Locations
- 1
- Primary Endpoint
- the number of participants who will have high level of bisphenol in btheir blood
Study Overview
Brief Summary
Polycystic ovary syndrome (PCOS) is the most common and the most heterogeneous endocrine disorder in premenopausal women. Its prevalence is estimated from 5 to 10% depending on the diagnosis' criteria .
Apart from signs of hyperandrogenism such as acne, hirsutism and hair loss; women with PCOS usually present with menstrual irregularities and fertility problems ..
Detailed Description
Bisphenol A is formed from acetone and phenol, it is used in production of epoxy resin, polyster resins and polyvarbonate resins. Epoxy resins are used in plastics, adhesives, and structural composites .
Humans are at the end of the food chain, thus they are exposed to the highest doses of these compounds. EDs have been detected in human adipose tissue and biological fluids such as: serum, urine, milk and amniotic fluid .
Additionally, it has been proven that BPA can also directly stimulate androgen synthesis in the ovarian theca-interstitial cells. A correlation between increased serum testosterone levels observed in women with PCOS with serum BPA concentrations has also been found .
Study Design
- Study Type
- Observational
- Observational Model
- Case Control
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 18 Years to 40 Years (Adult)
- Sex
- Female
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Age group: 18-40
- •Diagnosed a case of polycystic ovary syndrome
Exclusion Criteria
- •• Female patients with other acute or chronic illness
- •Cardiovascular disease
- •Neoplasms
- •Current smoking, diabetes mellitus,
- •Renal impairment (serum creatinine 120 mol/liter), and hypertension (blood pressure 140/85 mm Hg).
Outcomes
Primary Outcomes
the number of participants who will have high level of bisphenol in btheir blood
Time Frame: within 6 weeks
Secondary Outcomes
No secondary outcomes reported
Investigators
Mahmoud Alalfy
Assistant Researcher , National Research centre and Specialist of Obstetrics and Gynecology in Aljazeerah hospital
Aljazeera Hospital