Effectiveness of high flow nasal cannula versus non invasive ventilation in management of moderate to severe cases of pneumonia - a randomised controlled trial.
试验速览
- 阶段
- 2/3 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- 1. Improvement in PaO2/FiO2
研究概览
简要总结
Pneumonia with hypoxemic respiratory failure needs ICU admission along with oxygen therapy. There are various modalities of oxygen therapy such as conventional therapy with nasal cannula and face mask, high flow nasal cannula(HFNC) and noninvasive ventilation(NIV). High flow nasal cannula is less studied amongst all the modalities. Rationale of this study is to compare high flow nasal cannula with non invasive ventilation in patients of moderate to severe pneumonia requiring oxygen therapy.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- None
入排标准
- 年龄范围
- 18.00 Year(s) 至 85.00 Year(s)（—）
- 性别
- All
入选标准
- •Patients with moderate to severe pneumonia (CURB65 more than 2) requiring oxygenation (PaO2/FiO2 less than 300) (PaO2 less than 60).
- •Patints more than 18 years of age.
排除标准
- •Patients having contraindications of HFNC and NIV.
- •Patients requiring mechanical ventilation.
- •Patients not giving consent.
结局指标
主要结局
1. Improvement in PaO2/FiO2
时间窗: 1. Improvement in PaO2/FiO2 after 72 hours of HFNC/ NIV | 2. Improvement in PaO2 after 72 hours of HFNC / NIV | 3.Improvement in Respiratory rate after 72 hours of HFNC / NIV | 4. Improvement in SpO2
2. Improvement in PaO2
时间窗: 1. Improvement in PaO2/FiO2 after 72 hours of HFNC/ NIV | 2. Improvement in PaO2 after 72 hours of HFNC / NIV | 3.Improvement in Respiratory rate after 72 hours of HFNC / NIV | 4. Improvement in SpO2
3.Improvement in Respiratory rate
时间窗: 1. Improvement in PaO2/FiO2 after 72 hours of HFNC/ NIV | 2. Improvement in PaO2 after 72 hours of HFNC / NIV | 3.Improvement in Respiratory rate after 72 hours of HFNC / NIV | 4. Improvement in SpO2
4. Improvement in SpO2
时间窗: 1. Improvement in PaO2/FiO2 after 72 hours of HFNC/ NIV | 2. Improvement in PaO2 after 72 hours of HFNC / NIV | 3.Improvement in Respiratory rate after 72 hours of HFNC / NIV | 4. Improvement in SpO2
次要结局
- To study efficacy of NIV and HFNC in patients with moderate to severe pneumonia.(2. To study compliance of NIV and HFNC in patients.)
研究者
Neha Rane
N. K. P. Salve Institute Of Medical Sciences & Research Centre Nagpur