Effectiveness of high flow nasal cannula versus non invasive ventilation in management of moderate to severe cases of pneumonia - a randomised controlled trial.
Overview
- Phase
- Phase 2/3
- Status
- Not yet recruiting
- Sponsor
- NKP Salve Institure of Medical Sciences and Research Centre and Lata Mangeshkar Hospital
- Enrollment
- 60
- Locations
- 1
- Primary Endpoint
- 1. Improvement in PaO2/FiO2
Overview
Brief Summary
Pneumonia with hypoxemic respiratory failure needs ICU admission along with oxygen therapy. There are various modalities of oxygen therapy such as conventional therapy with nasal cannula and face mask, high flow nasal cannula(HFNC) and noninvasive ventilation(NIV). High flow nasal cannula is less studied amongst all the modalities. Rationale of this study is to compare high flow nasal cannula with non invasive ventilation in patients of moderate to severe pneumonia requiring oxygen therapy.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Masking
- None
Eligibility Criteria
- Ages
- 18.00 Year(s) to 85.00 Year(s) (—)
- Sex
- All
Inclusion Criteria
- •Patients with moderate to severe pneumonia (CURB65 more than 2) requiring oxygenation (PaO2/FiO2 less than 300) (PaO2 less than 60).
- •Patints more than 18 years of age.
Exclusion Criteria
- •Patients having contraindications of HFNC and NIV.
- •Patients requiring mechanical ventilation.
- •Patients not giving consent.
Outcomes
Primary Outcomes
1. Improvement in PaO2/FiO2
Time Frame: 1. Improvement in PaO2/FiO2 after 72 hours of HFNC/ NIV | 2. Improvement in PaO2 after 72 hours of HFNC / NIV | 3.Improvement in Respiratory rate after 72 hours of HFNC / NIV | 4. Improvement in SpO2
2. Improvement in PaO2
Time Frame: 1. Improvement in PaO2/FiO2 after 72 hours of HFNC/ NIV | 2. Improvement in PaO2 after 72 hours of HFNC / NIV | 3.Improvement in Respiratory rate after 72 hours of HFNC / NIV | 4. Improvement in SpO2
3.Improvement in Respiratory rate
Time Frame: 1. Improvement in PaO2/FiO2 after 72 hours of HFNC/ NIV | 2. Improvement in PaO2 after 72 hours of HFNC / NIV | 3.Improvement in Respiratory rate after 72 hours of HFNC / NIV | 4. Improvement in SpO2
4. Improvement in SpO2
Time Frame: 1. Improvement in PaO2/FiO2 after 72 hours of HFNC/ NIV | 2. Improvement in PaO2 after 72 hours of HFNC / NIV | 3.Improvement in Respiratory rate after 72 hours of HFNC / NIV | 4. Improvement in SpO2
Secondary Outcomes
- To study efficacy of NIV and HFNC in patients with moderate to severe pneumonia.(2. To study compliance of NIV and HFNC in patients.)
Investigators
Neha Rane
N. K. P. Salve Institute Of Medical Sciences & Research Centre Nagpur