NCT01551784已完成不适用
An Observational Study of Statin Treatment Induced HDL Changes - Effect on Cardiovascular Disease
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- AstraZeneca
- 入组人数
- 120,000
- 主要终点
- Time to first occurrence of hospitalization for acute myocardial infarction, unstable angina pectoris or ischemic stroke related to changes in HDL-C
研究概览
简要总结
The aim with this study is to investigate the effect of statin induced changes in HDL-C on all cause mortality and CVD with adjustment for changes in other blood lipids and clinical parameters in Sweden, UK and the Netherlands.
详细描述
An observational study of statin treatment induced HDL changes - effect on cardiovascular disease
研究设计
- 研究类型
- Observational
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 86 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Started treatment with statins within the observation period (2004-2010)
- •The patient must have valid baseline and follow-up measurements for HDL-C and LDL-C.
排除标准
- •Malignancy Alcohol abuse/alcohol dependence
结局指标
主要结局
Time to first occurrence of hospitalization for acute myocardial infarction, unstable angina pectoris or ischemic stroke related to changes in HDL-C
时间窗: 1st of January 2004 to 31st December 2010
次要结局
- The effect of statin induced changes in HDL-C (per mmol/L) on a composite endpoint including unstable angina pectoris, myocardial infarction, ischemic stroke and all cause mortality.(1st of January 2004 to 31st December 2010)
- Time to first occurence of hospitalization for acute myocardial infarction, unstable angina pectoris or ischemic stroke and ischemic heart disease mortality related to changes in HDL-C.(1st of January 2004 to 31st December 2010)
- The relationships between acquired HDL levels after statin treatment on the primary endpoint and the effect of HDL increase on the primary endpoint for different levels of baseline HDL(1st of January 2004 to 31st December 2010)
- Potential interactions between baseline HDL and HDL increase and other factors like age, gender, treatment and co-morbidity on the primary endpoint(1st of January 2004 to 31st December 2010)
- The health economic consequences of increasing HDL-C with statin treatment(1st of January 2004 to 31st December 2010)
研究者
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