Comparison of the Post- Operative Analgesia in Haemorrhoidectomy patients after Peripheral Block using DEXMEDETOMIDINE VS CLONIDINE
试验速览
- 阶段
- Unknown
- 状态
- 已完成
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Duration of post-operative analgesia
研究概览
简要总结
A study was conducted to compare the duration of post-operative analgesia in patients undergoing haemorrhoidectomy who are given pudendal nerve block with either Clonidine or Dexmedetomidine alongwith local anaesthetic Bupivacaine in the operation theatre of Sree Gokulam Medical College and Research Foundation, Venjaramoodu, Trivandrum, Kerala. 60 patients were randomly divided into two groups of 30 each -- group C underwent pudendal block with 20ml of 0.25% Bupivacaine with Clonidine 1mcg / kg as additive and group D underwent pudendal block with 20ml of 0.25% Bupivacaine with Dexmedetomidine 1mcg/kg as additive . Complications like sedation, bradycardia and hypotension were also studied. The data was entered in excel and analysed using SPSS 20.0 and compared using t test and chi square test. There was significant difference in the duration of post-operative analgesia between the two groups. The duration of analgesia in group C was 761 +/_ 19.1 minutes while in group D it was 1184.57 +/_ 151.374 minutes. In pudendal nerve block, addition of Dexmeditomidine as an adjuvant to 0.25% Bupivacaine prolongs the duration of post-operative analgesia and is not associated with any major side effects. Both drugs have an added advantage of conscious sedation and haemodynamic stability, making them potential adjuvants for nerve blocks.
研究设计
- 研究类型
- Interventional
- 分配方式
- Computer generated randomization
- 盲法
- Participant Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 70.00 Year(s)(—)
- 性别
- All
入选标准
- •BMI<30 Normal coagulation parameters and platelet count(>100000) No systemic infection.
排除标准
- •BMI>30 Severe liver renal or cardiac disease Allergy or contraindications to any of the study drugs Previous surgery in the anal canal Pain or chronic analgesic administration in the preoperative period Abnormal coagulation parameters and platelet count(<100000) Systemic infection Patient requesting general anaesthesia.
结局指标
主要结局
Duration of post-operative analgesia
时间窗: Post operative monitoring for 24 hours
次要结局
- Post operative haemodynamic stability(1,5,10,30,60,120,180,240,360,480,600,720 min after completion of injection)
- Sedation(Every 30 minutes for 24 hours during the postoperative period)
