Improving the accuracy of determination of onset of neuromuscular block
Completed
- Conditions
- muscle disease10029317
- Registration Number
- NL-OMON32338
- Lead Sponsor
- niversitair Medisch Centrum Groningen
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 10
Inclusion Criteria
• General anaesthesia for two hours or more
• ASA class I or II
• Administration of rocuronium for intubation only
• Administration of propofol for anaesthesia induction and maintenance
• Operation allows neuromuscular monitoring using the TOF-Watch at the adductor pollicis muscle
• Age 18-70 years
• BMI < 30
Exclusion Criteria
• Administration of drugs interfering with neuromuscular block or monitoring
• Neuromuscular disease
• Diabetes mellitus type I or II
• Allergy to rocuronium
• Allergy to propofol
• Conditions interfering with neuromuscular monitoring using the TOF-Watch
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The main study parameters are the prediction accuracy of a PK-PD-potentiation<br /><br>model fitted with a Bayesian procedure to the twitch response data gathered at<br /><br>the adductor pollicis (thumb) from 1 Hz ST neuromuscular stimulation. Bayesian<br /><br>prior values for PK model parameters will be obtained from relevant<br /><br>literature. </p><br>
- Secondary Outcome Measures
Name Time Method <p>The secondary study parameters are the onset profile of (modeled) neuromuscular<br /><br>block predicted by the fitted PK-PD-potentiation model.</p><br>