Dual Energy Computer tomography in acute and chronic myocardic infarction.

Recruiting

Conditions: Myocardial infarction
heart attack
10082206

Registration Number: NL-OMON34601

Lead Sponsor: Erasmus MC, Universitair Medisch Centrum Rotterdam

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 140

Inclusion Criteria

Patients with acute myocardial infarction
- Age>40 years
- Onset of symptoms no more than 14 days before CT and MRI;If Acute no ST-elevation myocardial infarction (NSTEMI)
- Clinical presentation: rest angina/ new-onset severe angina/ increasing angina
- ST segment depression >=0.05mV or inverted T waves >=0.2mV
- Detection of troponine T or CK elevation over a period of 24-48 hours
- Imaging evidence of new loss of viable myocardium or new regional wall motion abnormalities;Patients with chronic myocardial infarction
- Age>40 years
- Impaired left ventricle ejection fraction
- Regional myocardial dysfunction

Exclusion Criteria

Clinical contraindications:
- Ongoing ischemia
- Relevant arrhythmias
- Coronary artery by-pass graft (CABG)
- Impaired renal function (serum creatinine>120 *mol/l or GFR<60 ml/min)
- Hemodynamic instability
- Possible pregnancy and breast feeding
- Body weight exceeding 120 kg
- Inability to breath hold for up 15 seconds
Contraindications for CT coronary angiography, including:
- Known allergy to iodated contrast material
Contraindications for MRI, including:
- MR incompatible metal in the body (pacemaker, metal implants, cerebral aneurysm clips, *)
- Severe claustrophobia
- Known allergy to gadolinium-based contrast material

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Assessment of the presence of myocardial infarction per coronary distribution<br /><br>on Dual Energy CT images, using MR as the reference standard. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>assessment of the presence of no-reflow areas per coronary distribution on Dual<br /><br>Energy CT images, using MR as the reference standard<br /><br>visual-semiquantitative analysis of scar tissue<br /><br>manual planimetry for the quantification of the scar tissue</p><br>