Dual Energy Computer tomography in acute and chronic myocardic infarction. - Demi study

Erasmus MC, Universitair Medisch Centrum Rotterdam0 个研究点目标入组 140 人开始时间: 待定最近更新: 2024年5月6日

适应症

试验速览

暂无简介。

•Patients with acute myocardial infarction
•- Age>40 years
•- Onset of symptoms no more than 14 days before CT and MRI;If Acute no ST-elevation myocardial infarction (NSTEMI)
•- Clinical presentation: rest angina/ new-onset severe angina/ increasing angina
•- ST segment depression >=0.05mV or inverted T waves >=0.2mV
•- Detection of troponine T or CK elevation over a period of 24-48 hours
•- Imaging evidence of new loss of viable myocardium or new regional wall motion abnormalities;Patients with chronic myocardial infarction
•- Age>40 years
•- Impaired left ventricle ejection fraction
•- Regional myocardial dysfunction

•Clinical contraindications:
•- Ongoing ischemia
•- Relevant arrhythmias
•- Coronary artery by-pass graft (CABG)
•- Impaired renal function (serum creatinine>120 *mol/l or GFR<60 ml/min)
•- Hemodynamic instability
•- Possible pregnancy and breast feeding
•- Body weight exceeding 120 kg
•- Inability to breath hold for up 15 seconds
•Contraindications for CT coronary angiography, including:
•- Known allergy to iodated contrast material
•Contraindications for MRI, including:
•- MR incompatible metal in the body (pacemaker, metal implants, cerebral aneurysm clips, *)
•- Severe claustrophobia
•- Known allergy to gadolinium-based contrast material

发起方