Portsmouth Clinical Outcomes REsearch Database (CORE-D)- a Research Database of Routine Electronically Recorded Patient Data to Model Adverse Clinical Outcomes and Healthcare Resource Usage
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 750,000
- 试验地点
- 2
- 主要终点
- In-hospital death
研究概览
简要总结
An integrated database of depersonalised routine hospital patient data consisting of demographic and disease attributes, physiological or laboratory measurements, care contacts and interventions along with associated clinical outcomes. The database is an essential resource for the development and testing of risk models and classification systems, modified as necessary for patient subgroups, which can then be introduced into clinical care to improve patient outcomes. It can also be used for large scale simulations to evaluate interventions.
详细描述
The aims and objectives of this database of depersonalised routinely collected hospital patient data are to:
- Conduct epidemiological and observational studies of acute hospital care.
- Develop and use algorithms and risk models to identify the deteriorating / sick adult so that interventions and enhanced care can be provided in a timelier manner with consequent resource and outcome improvements. This covers both the deteriorating inpatient at risk of adverse outcomes and people in the local community at risk of hospitalisation or in need of other health services.
- Retrospectively evaluate interventions e.g. impact of system-wide clinical pathway introduction
- Conduct simulations of clinical pathways
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 16 Years 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult presenting at the acute hospital or receiving services from the hospital
排除标准
- •Adults who have registered an opt out of research with National Health Service (NHS) Digital
- •Adults who have contacted the hospital to ask that their records are not to be included in this study
结局指标
主要结局
In-hospital death
时间窗: 30 days after admission
Death during hospital admission
Unanticipated ICU admission
时间窗: 30 days after admission
Unanticipated ICU admission during hospital stay
Cardiac arrest
时间窗: 30 days after admission
Cardiac arrest during hospital stay
In-hospital death
时间窗: At 24 hours after an observation assessment or physiological measurement
Death during hospital admission
Unanticipated ICU admission
时间窗: At 24 hours after an observation assessment or physiological measurement
Unanticipated ICU admission during hospital stay
Cardiac arrest
时间窗: At 24 hours after an observation assessment or physiological measurement
Cardiac arrest during hospital stay
次要结局
- Diagnosis of Corona Virus Disease (COVID) infection(At 48 hours after an observation assessment or physiological measurement)
- Detection of Acute Organ Dysfunction(30 days after presentation)
- Diagnosis of Corona Virus Disease (COVID) infection(48 hours after presentation)
- Detection of Acute Organ Dysfunction(24 hours after presentation)
- Detection of Acute Organ Dysfunction(48 hours after presentation)
- Detection of Acute Organ Dysfunction(72 hours after presentation)
- Detection of Acute Organ Dysfunction(1 week after presentation)