Hypoperfusion-hypodensity Mismatch for the Identification of Patients With Stroke Within 4.5 Hours
Completed
- Conditions
- Acute Ischemic Stroke
- Registration Number
- NCT04277728
- Lead Sponsor
- University Hospital Muenster
- Brief Summary
Intravenous thrombolysis is recommended within 4.5 hours of stroke onset. The aim of the study is to evaluate whether a hypodensity on native CT within the virtually entire area of hypoperfusion on perfusion CT, i.e. hypoperfusion-hypodensity mismatch, identifies patients within the time window of thrombolysis in a multicenter cohort. The investigators hypothesize hypoperfusion-hypodensity mismatch will identify patients ≤ 4,5 hours of symptom onset with \>70% specificity and \>85% positive predictive value.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 689
Inclusion Criteria
- acute ischemic stroke
- evidence of acute intracranial vessel occlusion (any supratentorial proximal or peripheral artery of the anterior cerebral artery, middle cerebral artery or posterior cerebral artery territory) by CT hyper dense thrombus and/or CTangiography vessel occlusion and/or by ischemic perfusion deficit
- evidence for acute ischemic perfusion deficit, i.e. acute symptoms attributable to ischemic CT perfusion lesion
- complete native CT and CTperfusion performed on admission
- sufficient CT and CTperfusion quality for judgement of acute ischemic hypodensity
- known time of symptom onset.
Exclusion Criteria
- None
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Specificity of "hypoperfusion hypodensity mismatch" for the identification of patients ≤4.5 hours on admission Positive predictive value of "hypoperfusion hypodensity mismatch" for the identification of patients ≤4.5 hours on admission
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
University Hospital Münster
🇩🇪Münster, Germany