NCT02178969
Completed
Not Applicable
A Prospective Short-term Study to Evaluate Methodologies for the Assessment of Disease Extent, Impact, and Wound Evolution in Patients With Dystrophic Epidermolysis Bullosa (DEB)
ConditionsDystrophic Epidermolysis Bullosa
Overview
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Shire
- Enrollment
- 29
- Locations
- 10
- Primary Endpoint
- Wound Surface Area (WSA) of patient- and investigator-selected wounds
Overview
Brief Summary
The purpose of this study is to better understand disease extent and to identify appropriate methodologies to evaluate (dystrophic epidermolysis bullosa) DEB in a quantitative and qualitative manner.
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Prospective
Eligibility Criteria
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Written informed consent is provided. Patients 18 years of age and older, and parent(s)/legal guardian(s) of patients younger than 18 years of age, must provide written informed consent prior to participating in the study; additionally, informed assent will be obtained from patients younger than 18 years of age as specified by local requirements.
- •Patient must have a documented diagnosis of DEB based on genetic analysis showing a mutation in COL7A1 or, in the opinion of the investigator, a confirmed diagnosis of DEB based on histologic criteria (antigen mapping or electron microscopy).
- •Patient must have at least 5 wounds that are suitable for imaging, in the opinion of the investigator, at the time of enrollment.
- •Patient is willing and able to undergo the protocol-specified procedures.
Exclusion Criteria
- •Patient has used or is currently using experimental treatment for DEB including, but not limited to, bone marrow transplantation, systemic immune suppression, or experimental procedures that involve live cells, with potential for systemic spread such as gene transfer, stem cell infusions, or other cell type injections such that, in the opinion of the investigator, inclusion poses an unacceptable risk to the patient or interpretation of these study data.
- •Patient has squamous cell carcinoma with evidence of locally invasive disease or distant metastases.
- •Patient is pregnant.
Outcomes
Primary Outcomes
Wound Surface Area (WSA) of patient- and investigator-selected wounds
Time Frame: Over 4 weeks
Wound Surface Area (WSA) as a percentage of Body Surface Area (BSA) in patients with DEB
Time Frame: Over 4 weeks
Secondary Outcomes
- The number, severity and relationship to study procedures of adverse events (AEs) and serious AEs (SAEs)(Over 4 weeks)
Investigators
Study Sites (10)
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