The Effect of Oral Vitamin D3 Supplementation on Spermogram Quantitative and Qualitative Indicators in Infertile Male
- Conditions
- Infertility.Male infertility
- Registration Number
- IRCT2016111830947N1
- Lead Sponsor
- Vice chancellor for research, Iran University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- Male
- Target Recruitment
- 60
inclusion criteria: Be healthy physically and mentally ? older than 20 years and less than 45 years? body mass index is 18/5-30? not to intake any vitamin D3 at therapeutic doses in last 3 months? not to intake supplementation in non?therapeutic doses in last 3 months? not to intake medications that influence on the level of vitamin D3 includes? glucocorticoids and anti convulsion? the drugs that influence on spermatogenesis such as cimetidine? spirnolactone should not have be used according to urologist in last 3 months? lack of Azoospermia in spermogram? having disrupt sperm of unknown origin(idiopatice)? lack of genital tract infection or drug treatment in this regard during the past three months according to the clinical records and according to patients saying? lack of anatomical abnormalities of the genital tract such as varicocele grade two and above? Testes and vas deferens history of surgery? no contact with pesticides? heavy metals and high temperature? not using cigarette or hookah in last 3 month? not using alcohol or narcotic? the serum level of vitamin D3 should be less than 30 or equal to 30 Ng in liter? no disorder in prolactine levels or TSH.
exclusion criteria:
not taking more than one dose of vitamin D3? the existence of some signs or symptoms wich prohibit the continuous of using according to urologist and nutritionnist? start taking other supplements drugs that have been banned their entry criteria during the study
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Spermogram Qualitative Indicators. Timepoint: Patients are tested twice for Spermogram Qualitative Indicators.(one day before the first day of training – one day after the final day training course). Method of measurement: Spermogram.;Spermogram Quantitative Indicators. Timepoint: Patients are tested twice for Spermogram Quantitative Indicators.(one day before the first day of training – one day after the final day training course). Method of measurement: Spermogram.
- Secondary Outcome Measures
Name Time Method Hormonal markers related to spermatogenesis(LH? FSH? TT? FT? SHBG. Timepoint: Patients are tested twice for Hormonal markers related to spermatogenesis.(one day before the first day of training – one day after the final day training course). Method of measurement: Evaluation of serum levels.