The Effect of Dietary Nucleotides and Ribose on Muscle Fuel Utilisation and Exercise Performance
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 13
- 试验地点
- 2
- 主要终点
- Changes in muscle ATP concentrations
研究概览
简要总结
Nucleotides are the building blocks for a variety of molecules, including ATP, which is broken down in the skeletal muscle cells to provide fuel for exercise. Nucleotides can be obtained from the diet, and produced or salvaged by the body. Though nucleotides provide the building blocks for ATP, the sugar ribose has been suggested to be rate limiting for synthesising ATP.
Previous studies have shown a decrease in ATP levels in the muscle after intense exercise, and this is linked to fatigue. Other studies have also reported benefits of nucleotide and/or ribose supplementation on exercise performance. However, any potential link between ATP metabolism and exercise performance has not been explored.
This study will look at the effects of nucleotide and nucleotide-ribose supplementation in fuel utilisation and performance in skeletal muscle during endurance exercise.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •BMI between 18 and 30
排除标准
- •On medication (except contraception)
- •Diagnosed with any metabolic or cardiovascular conditions
- •Muscle or bone injuries
- •BMI < 18 or > 30
结局指标
主要结局
Changes in muscle ATP concentrations
时间窗: After each supplementation cycle (day 15 of each cycle): baseline (fasted and before exercise), immediately after glycogen depleting exercise (after exercising for 1:30 - 2 hours), immediately after 15 minute time trial and after 3-hour recovery
次要结局
- Changes in muscle glycogen concentrations(After each supplementation cycle (day 15 of each cycle): baseline (fasted and before exercise), immediately after glycogen depleting exercise (after exercising for 1:30 - 2 hours), immediately after 15 minute time trial and after 3-hour recovery)
- Blood lactate concentrations(After supplementation cycle (day 15): baseline and at 15 minute intervals up 1 hour during glycogen depleting exercise)
- Serum uric acid concentrations(Measured at baseline and of days 6, 8 and 15 of each supplementation cycle)
- Blood glucose concentrations(After supplementation cycle (day 15): baseline and at 15 minute intervals up 1 hour during glycogen depleting exercise)