Dietary Nucleotides and Ribose on Muscle Fuel Utilisation
- Conditions
- Healthy
- Interventions
- Dietary Supplement: High nucleotideDietary Supplement: High nucletide + RiboseDietary Supplement: Low nucleotide
- Registration Number
- NCT03659890
- Lead Sponsor
- University of Exeter
- Brief Summary
Nucleotides are the building blocks for a variety of molecules, including ATP, which is broken down in the skeletal muscle cells to provide fuel for exercise. Nucleotides can be obtained from the diet, and produced or salvaged by the body. Though nucleotides provide the building blocks for ATP, the sugar ribose has been suggested to be rate limiting for synthesising ATP.
Previous studies have shown a decrease in ATP levels in the muscle after intense exercise, and this is linked to fatigue. Other studies have also reported benefits of nucleotide and/or ribose supplementation on exercise performance. However, any potential link between ATP metabolism and exercise performance has not been explored.
This study will look at the effects of nucleotide and nucleotide-ribose supplementation in fuel utilisation and performance in skeletal muscle during endurance exercise.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 13
- BMI between 18 and 30
- On medication (except contraception)
- Smokers
- Diagnosed with any metabolic or cardiovascular conditions
- Muscle or bone injuries
- BMI < 18 or > 30
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description High nucleotide High nucleotide 2 week supplementation with a high nucleotide mycoprotein drink, with added dextrose High nucletide + Ribose High nucletide + Ribose 2 week supplementation with a high nucleotide mycoprotein drink, with added ribose Low nucleotide Low nucleotide 2 week supplementation with a low nucleotide mycoprotein drink, with added dextrose
- Primary Outcome Measures
Name Time Method Changes in muscle ATP concentrations After each supplementation cycle (day 15 of each cycle): baseline (fasted and before exercise), immediately after glycogen depleting exercise (after exercising for 1:30 - 2 hours), immediately after 15 minute time trial and after 3-hour recovery
- Secondary Outcome Measures
Name Time Method Changes in muscle glycogen concentrations After each supplementation cycle (day 15 of each cycle): baseline (fasted and before exercise), immediately after glycogen depleting exercise (after exercising for 1:30 - 2 hours), immediately after 15 minute time trial and after 3-hour recovery Blood lactate concentrations After supplementation cycle (day 15): baseline and at 15 minute intervals up 1 hour during glycogen depleting exercise Serum uric acid concentrations Measured at baseline and of days 6, 8 and 15 of each supplementation cycle Blood glucose concentrations After supplementation cycle (day 15): baseline and at 15 minute intervals up 1 hour during glycogen depleting exercise
Trial Locations
- Locations (1)
University of Exeter - St Luke's Campus
🇬🇧Exeter, Devon, United Kingdom