MedPath

Dietary Nucleotides and Ribose on Muscle Fuel Utilisation

Not Applicable
Completed
Conditions
Healthy
Interventions
Dietary Supplement: High nucleotide
Dietary Supplement: High nucletide + Ribose
Dietary Supplement: Low nucleotide
Registration Number
NCT03659890
Lead Sponsor
University of Exeter
Brief Summary

Nucleotides are the building blocks for a variety of molecules, including ATP, which is broken down in the skeletal muscle cells to provide fuel for exercise. Nucleotides can be obtained from the diet, and produced or salvaged by the body. Though nucleotides provide the building blocks for ATP, the sugar ribose has been suggested to be rate limiting for synthesising ATP.

Previous studies have shown a decrease in ATP levels in the muscle after intense exercise, and this is linked to fatigue. Other studies have also reported benefits of nucleotide and/or ribose supplementation on exercise performance. However, any potential link between ATP metabolism and exercise performance has not been explored.

This study will look at the effects of nucleotide and nucleotide-ribose supplementation in fuel utilisation and performance in skeletal muscle during endurance exercise.

Detailed Description

Not available

Recruitment & Eligibility

Status
COMPLETED
Sex
All
Target Recruitment
13
Inclusion Criteria
  • BMI between 18 and 30
Read More
Exclusion Criteria
  • On medication (except contraception)
  • Smokers
  • Diagnosed with any metabolic or cardiovascular conditions
  • Muscle or bone injuries
  • BMI < 18 or > 30
Read More

Study & Design

Study Type
INTERVENTIONAL
Study Design
CROSSOVER
Arm && Interventions
GroupInterventionDescription
High nucleotideHigh nucleotide2 week supplementation with a high nucleotide mycoprotein drink, with added dextrose
High nucletide + RiboseHigh nucletide + Ribose2 week supplementation with a high nucleotide mycoprotein drink, with added ribose
Low nucleotideLow nucleotide2 week supplementation with a low nucleotide mycoprotein drink, with added dextrose
Primary Outcome Measures
NameTimeMethod
Changes in muscle ATP concentrationsAfter each supplementation cycle (day 15 of each cycle): baseline (fasted and before exercise), immediately after glycogen depleting exercise (after exercising for 1:30 - 2 hours), immediately after 15 minute time trial and after 3-hour recovery
Secondary Outcome Measures
NameTimeMethod
Changes in muscle glycogen concentrationsAfter each supplementation cycle (day 15 of each cycle): baseline (fasted and before exercise), immediately after glycogen depleting exercise (after exercising for 1:30 - 2 hours), immediately after 15 minute time trial and after 3-hour recovery
Blood lactate concentrationsAfter supplementation cycle (day 15): baseline and at 15 minute intervals up 1 hour during glycogen depleting exercise
Serum uric acid concentrationsMeasured at baseline and of days 6, 8 and 15 of each supplementation cycle
Blood glucose concentrationsAfter supplementation cycle (day 15): baseline and at 15 minute intervals up 1 hour during glycogen depleting exercise

Trial Locations

Locations (1)

University of Exeter - St Luke's Campus

🇬🇧

Exeter, Devon, United Kingdom

© Copyright 2025. All Rights Reserved by MedPath