Wound Closure After Total Knee Arthroplasty: Comparison of Polypropylene and Polyglactin 910 Suture.

Not Applicable

Completed

• Conditions: Wound Complication; Wound Heal; Wound Dehiscence
• Interventions: Procedure: wound closure

• Registration Number: NCT06373900
• Lead Sponsor: Indus Hospital and Health Network

Brief Summary

Comparison of wound complication and scar formation in patient undergone bilateral total knee replacement comparison between polypropylene and polyglactin 910 suture. patient randomised according to SNOS protocol into group A and B for their right and left knee closure with each suture. patient followed on 3rd, 7th, 15th and 30th post operative day for wound healing, wound dehiscence and scar formation.

Detailed Description

All patients aged 50-80 years, belonging to either sex, diagnosed with end-stage osteoarthritis or post-traumatic arthritis, and scheduled for bilateral primary total knee arthroplasty at the Department of Orthopedics, Indus Hospital and Health Network, Karachi were enrolled in the study. Exclusion criteria included patients having existing skin, neuromuscular, or connective tissue disorders, rheumatoid arthritis, immunosuppression, morbid obesity, and pregnancy. All patients provided voluntary informed written consent before enrolment in the study.

In all patients undergoing primary TKA, one knee was closed using polypropylene, whereas the other was closed with Polyglactin 910 sutures. All surgeries were performed by the same surgical team using a standard medial parapatellar approach. The number of sutures and wound closure techniques were standardized across both groups.

Study Timeline

• Study Start: 2022-02-13
• Primary Completion: 2022-02-19
• Study Completion: 2022-03-30
• Study First Submitted: 2024-03-25
• Status Verified: 2024-04
• Study First Submitted QC: 2024-04-15
• Last Update Submitted: 2024-04-15
• Study First Posted: 2024-04-18
• Last Update Posted: 2024-04-18

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• Age 50 to 80 years
• Both gender
• Inform consent
• End stage osteoarthritis

Exclusion Criteria

• Age less the 50 and more then 80
• BMI more then 40
• Rheumatoid Arthritis
• lack of consent
• Pregnant female

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Group A	wound closure	wound closure with polypropylene
Group B	wound closure	wound closure with polyglactin 910 suture

Primary Outcome Measures

Name	Time	Method
Wound Infection Grade	30 days after surgery	wound infection grade assessed on post operative day 3rd, 7th, 15th and 30th as simple stitch abscess, surrounding cellulitis, any systematic symptoms or suture removed.
Wound characteristics and complications	30 days after surgery	Post operative patient followed on 3rd, 7th, 15th and 30th day for the assessment of any erythema, wound dehiscence, discharge, blister around the wound, warmth and tenderness
Hollander Cosmetic Wound Evaluation Score	30 days after surgery	Hollander score assessed on 3rd, 7th, 15th and 30th post operative day as step off border, contour, scar width, scar width, edge inversion and overall cosmesis

Trial Locations

Locations (1)

Indus Hospital and Health Network; 🇵🇰 Karachi, Sindh, Pakistan