Efficacy of intranasal fentanyl for the treatment of moderate to severe pain in adult patients in the emergency department

Peninsula Health0 个研究点目标入组 150 人开始时间: 2013年6月12日最近更新: 2020年1月13日

试验速览

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•Age greater or equal to 18 years
•Self-report pain severity as being greater than or equal to 6 on the standard 11-point verbal rating scale, where 0 is no pain and 10 is the worst pain imaginable
•Medical recommendation for parenteral analgesia (attending doctor’s discretion)
•Pain from any cause other than the specific exclusion criteria (see below)

•Known allergy or previous adverse reaction to fentanyl
•Use of oral, intranasal or parenteral narcotic analgesia in previous 4 hours (either pre-hospital or in the emergency department) [NB. Pre-hospital use of short-acting inhaled methoxyfluorane alone or non-narcotic analgesics do not constitute an exclusion]
•MAO Inhibitor antidepressant use within last 14 days
•Haemodynamic instability (eg HR > 120/min or BP < 90 mmHg) with the need for time critical interventions of any type
•Suspicion of any of the following medical conditions:
•myocardial ischaemia (concern re transient hypotension from fentanyl)
•suspected subarachnoid haemorrhage (concern re transient hypotension from fentanyl)
•migraine (specific proven therapy)
•Relative contraindication to, or anticipated difficulty with nasal administration of medication that may prevent adequate administration or absorption of intranasal medication (eg aberrant nasal anatomy, acute or chronic nasal problems or nasal trauma).
•Presence of acute cognitive impairment (any underlying cause)
•Schizophrenia or related psychiatric conditions (even if currently well controlled)
•History of recreational substance abuse
•Inability to understand study explanation or procedures, or to provide informed consent
•Pregnancy, breast feeding

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