Identification of biomarkers, functional parameters and clinical risk factors predisposing for the development of pulmonary chronic GVHD after allogeneic hematopoietic stem cell transplantation.
- Conditions
- obliterative bronchiolitis, bronchiolitis obliterans with organizing pneumonia (BOOP), non-classifiable interstitial pneumonia (NCIP)chronic GVHD, ICD-10: T86.05, T86.06, T86.07T86.06
- Registration Number
- DRKS00003304
- Lead Sponsor
- Westdeutsches TumorzentrumKlinik für KnochenmarktransplantationUniversitätsklinikum Essen
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 125
Inclusion Criteria
free of relapse after allogeneic HSCT
Exclusion Criteria
relapse
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Incidence rates of obliterative bronchiolitis (BO), bronchiolitis obliterans with organizing pneumonia (BOOP), non-classifiable interstitial pneumonia (NCIP). Correlation with clinical risk factors and Biomarkers (TIM-1a, Elafin, BAF, NFkappaB, TGFbeta, HIF1a, Il-17, FoxP3, INOS, IDO, TLR-2, TLR-9, Wnt/beta-catenin, sIl-2, T-regs)
- Secondary Outcome Measures
Name Time Method Incidence rates of chronic GVHD. Correlation with clinical risk factors and Biomarkers (TIM-1a, Elafin, BAF, NFkappaB, TGFbeta, HIF1a, Il-17, FoxP3, INOS, IDO, TLR-2, TLR-9, Wnt/beta-catenin, sIl-2, T-regs)