NCT03642288Unknown不适用
The Use of Gastrografin in Chronic Radiation Enteropathy With Small Bowel Obstruction：A Retrospective Study
Jinling Hospital, China0 个研究点目标入组 112 人开始时间: 2014年4月1日最近更新:
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 112
- 主要终点
- The rate of successful conservative treatment
研究概览
简要总结
Chronic radiation enteropathy (CRE) is a major issue for long-term cancer survivors. The aim of this study was to clarify the diagnostic and therapeutic effect of the Gastrografin (GG) challenge for patients with CRE induced small bowel obstruction SBO.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Care Provider, Investigator)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •with a first diagnosis of CRE combined with SBO and ASBO that was determined by clinical history, computed tomography (CT) manifestation, and confirmed by intraoperative and histologic findings.
- •radiation therapy completed at least 6 months before enrolment.
排除标准
- •a colostomy or ileostomy;
- •large bowel obstruction;
- •with a known history of either allergy or hypersensitivity to iodinated contrast agents;
- •with signs of strangulation;
- •metastatic disease;
- •obstruction within 4 weeks after a recent operation or serious comorbidity.
研究组 & 干预措施
CRE-induced SBO
Experimental
Patients with CRE-induced SBO received GG challenge.
干预措施: Gastrografin (Drug)
ASBO
Active Comparator
Patients with adhesive SBO (ASBO) received GG challenge.
干预措施: Gastrografin (Drug)
结局指标
主要结局
The rate of successful conservative treatment
时间窗: 5 days
The rate of patients who need for operative intervention within 48 hours of randomization.
次要结局
- The length of hospital stays(2 weeks)
- The time to resolution(2 weeks)
研究者
Ding Chao
Clinical Doctor
Jinling Hospital, China
相似试验
Unknown
不适用
Prospective Evaluation of Gastrointestinal and Genitourinary Side Effects of Pelvic RadiotherapyRadiotherapy Side EffectsNCT05407116McGill University Health Centre/Research Institute of the McGill University Health Centre147
尚未招募
3 期
PE-Bacon for Late Complications of Chronic Radiation-induced Rectal InjuryChronic Radiation InjuryNCT05607927Sixth Affiliated Hospital, Sun Yat-sen University316
Unknown
不适用
Clinical Study Assessing the Effect of ZIVEREL® in Cancer PatientsAcute EsophagitisNCT04070677Grupo de Investigación Clínica en Oncología Radioterapia200
终止
4 期
The Effect of Chemoradiotherapy on Gastric Perfusion in Patients With Gastric Cancer.Gastric CancerNCT05354856Rigshospitalet, Denmark11
招募中
3 期
Prevention of Radiotherapy Induced Enteropathy by Probiotics (PREP)RadiotherapyToxicityDiarrheaProbioticsNCT03978949Asan Medical Center248