Role of the Sympathetic Nervous System in Rosacea
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 4
- 主要终点
- Skin sympathetic nerve activity
研究概览
简要总结
Rosacea is a common skin disorder which causes facial redness and inflammation in about 16 million Americans, from an unknown cause. Many triggers of rosacea symptoms are stressors that affect the sympathetic ("fight or flight") portion of the nervous system, and a recent pilot study suggests there is sympathetic dysfunction in rosacea. This project will benefit patients, clinicians, and basic scientists by increasing our understanding of sympathetic nervous system involvement in rosacea symptoms in order to develop improved treatments for patients with rosacea.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Otherwise healthy males and non-pregnant/non-lactating females with mild to moderate erythematotelangiectactic rosacea, as well as age-sex matched healthy control subjects.
排除标准
- •Neurological, cardiovascular, respiratory, metabolic, muscular, or other dermatological disorders
- •Current history of alcohol and/or drug abuse
- •Known allergies or hypersensitivities to medications/drugs that are used in the protocol
- •Current smoking or regular smoking within the last 2 years
- •Body mass index > 35 kg/m2
- •Medications or supplements which are known to affect neural, cardiovascular, or muscular responses
结局指标
主要结局
Skin sympathetic nerve activity
时间窗: Immediate (during the single-day study). This study consists of a one-day protocol, during which this outcome is measured.
microneurography
Skin blood flow
时间窗: Immediate (during the single-day study). This study consists of a one-day protocol, during which this outcome is measured.
laser Doppler flowmetry
次要结局
未报告次要终点
研究者
Kristen Metzler-Wilson
Associate Professor
Indiana University