Effects of Ursodeoxycholic Acid on Graft Recovery Early After Adult Liver Transplantation
Not Applicable
Completed
- Conditions
- Liver TransplantationIschemia-reperfusion InjuryCholestasis
- Interventions
- Drug: identical-appearing placebo
- Registration Number
- NCT01073202
- Lead Sponsor
- Shanghai Jiao Tong University School of Medicine
- Brief Summary
This study is designed to investigate the possible beneficial effects of UDCA on liver graft recovery early after adult liver transplantation.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 112
Inclusion Criteria
- All liver transplant patients in our center between May 2005 and April 2008 were potentially eligible for enrollment
Exclusion Criteria
- Age less than 18 years
- Treatment with UDCA within one month before operation
- Inability to provide written informed consent prior to study entry
- Non-liver organ(s) failure prior to entry
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description ursodeoxycholic acid ursodeoxycholic acid - identical-appearing placebo identical-appearing placebo -
- Primary Outcome Measures
Name Time Method Serum liver tests within the first 4 weeks after liver transplantation Serum liver tests include serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma glutamyl transpeptidase (GGT), alkaline phosphatase (ALP) and total bilirubin (TB)
- Secondary Outcome Measures
Name Time Method Postoperative complications within the first 4 weeks after liver transplantation Postoperative complications include rates of acute cellular rejection (ACR), drug-induced hepatotoxicity, vascular or biliary complications, recurrence of primary liver disease and death
Trial Locations
- Locations (1)
Shanghai First People's Hospital
🇨🇳Shanghai, Shanghai, China