Vestibular Function After Chemoradiotherapy for Nasopharyngeal Carcinoma

• Conditions: Nasopharyngeal Carcinoma

• Registration Number: NCT02505672
• Lead Sponsor: Rabin Medical Center

Brief Summary

Nasopharyngeal carcinoma (NPC) is usually treated with chemoradiotherapy. While the effects of this treatment on cochlear function is well characterized, its effect on vestibular function is not well studied.

In this study the investigators will study the vestibular function of 50 patients undergoing chemoradiotherapy for NPC both before and after treatment in order to better define its effects. All patients will undergo a validated questionnaire (dizziness handicap index), posturography, audiometry and vestibular-evoked myogenic potentials.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2015-07-18
• Study First Submitted QC: 2015-07-20
• Study First Posted: 2015-07-22
• Status Verified: 2016-04
• Last Update Submitted: 2016-04-16
• Last Update Posted: 2016-04-19
• Study Start: 2016-08
• Primary Completion: 2016-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• Age 18 years or older.
• Biopsy-proven NPC.
• About to undergo chemoradiotherapy with intensity-modulated radiotherapy (IMRT).

Exclusion Criteria

• Pregnancy.
• Prior vestibular dysfunction.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Subjective dizziness and vestibular dysfunction using the dizziness handicap index	6 months after completion of treatment
Hearing level using standard audiometry	6 months after completion of treatment
Objective vestibular function using posturography	6 months after completion of treatment
Vestibular saccular function using vestibular-evoked myogenic potentials	6 months after completion of treatment

Trial Locations

Locations (1)

Department of Otolaryngology, Rabin Medical Center; 🇮🇱 Petach Tikva, Israel