Vestibular Function After Chemoradiotherapy for Nasopharyngeal Carcinoma
试验速览
- 阶段
- 不适用
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Subjective dizziness and vestibular dysfunction using the dizziness handicap index
研究概览
简要总结
Nasopharyngeal carcinoma (NPC) is usually treated with chemoradiotherapy. While the effects of this treatment on cochlear function is well characterized, its effect on vestibular function is not well studied.
In this study the investigators will study the vestibular function of 50 patients undergoing chemoradiotherapy for NPC both before and after treatment in order to better define its effects. All patients will undergo a validated questionnaire (dizziness handicap index), posturography, audiometry and vestibular-evoked myogenic potentials.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age 18 years or older.
- •Biopsy-proven NPC.
- •About to undergo chemoradiotherapy with intensity-modulated radiotherapy (IMRT).
排除标准
- •Pregnancy.
- •Prior vestibular dysfunction.
结局指标
主要结局
Subjective dizziness and vestibular dysfunction using the dizziness handicap index
时间窗: 6 months after completion of treatment
Hearing level using standard audiometry
时间窗: 6 months after completion of treatment
Objective vestibular function using posturography
时间窗: 6 months after completion of treatment
Vestibular saccular function using vestibular-evoked myogenic potentials
时间窗: 6 months after completion of treatment
次要结局
未报告次要终点
研究者
yotam shkedy
Resident
Rabin Medical Center