Vestibular Function After Chemoradiotherapy for Nasopharyngeal Carcinoma
- Conditions
- Nasopharyngeal Carcinoma
- Interventions
- Radiation: Chemoradiotherapy for nasopharyngeal carcinoma
- Registration Number
- NCT02505672
- Lead Sponsor
- Rabin Medical Center
- Brief Summary
Nasopharyngeal carcinoma (NPC) is usually treated with chemoradiotherapy. While the effects of this treatment on cochlear function is well characterized, its effect on vestibular function is not well studied.
In this study the investigators will study the vestibular function of 50 patients undergoing chemoradiotherapy for NPC both before and after treatment in order to better define its effects. All patients will undergo a validated questionnaire (dizziness handicap index), posturography, audiometry and vestibular-evoked myogenic potentials.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 50
Inclusion Criteria
- Age 18 years or older.
- Biopsy-proven NPC.
- About to undergo chemoradiotherapy with intensity-modulated radiotherapy (IMRT).
Exclusion Criteria
- Pregnancy.
- Prior vestibular dysfunction.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Study group Chemoradiotherapy for nasopharyngeal carcinoma Patients older than 18 who are planned to undergo chemoradiotherapy for nasopharyngeal carcinoma.
- Primary Outcome Measures
Name Time Method Subjective dizziness and vestibular dysfunction using the dizziness handicap index 6 months after completion of treatment Hearing level using standard audiometry 6 months after completion of treatment Objective vestibular function using posturography 6 months after completion of treatment Vestibular saccular function using vestibular-evoked myogenic potentials 6 months after completion of treatment
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Department of Otolaryngology, Rabin Medical Center
🇮🇱Petach Tikva, Israel