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临床试验/NCT00203762
NCT00203762Unknown不适用

Effect of the South African Public Sector Antiretroviral Treatment Programme on the Performance of Tuberculosis and Immunization Programmes - A Cluster Controlled (Non-Randomized) Trial

University of Cape Town2 个研究点 分布在 1 个国家目标入组 39 人开始时间: 2003年5月最近更新:
适应症

试验速览

阶段
不适用
入组人数
39
试验地点
2
主要终点
Measles immunization completed by 18 months

研究概览

简要总结

A scale-up of public sector antiretroviral treatment (ART) programmes may divert scarce resources from other priority primary care programmes like tuberculosis and childhood immunization.

The purpose of this study is to compare the performance of tuberculosis (TB) and childhood immunization programmes in primary care facilities participating in the South African national antiretroviral treatment programme with those which have yet to be included in the ART programme.

详细描述

Large-scale public sector antiretroviral treatment programmes, like those planned for sub-Saharan Africa, will compete for scarce resources, in particular scarce human resources, with other priority primary care programmes like tuberculosis and childhood immunization.

This could lead to impaired performance in other priority programmes like childhood immunization while health workers are distracted by the demands of establishing and maintaining ART programmes. On the other hand, ART provisions may have positive spin-offs for related programmes like improved case detection of tuberculosis among HIV-positive patients seeking ART. The impact of the ART programme on primary healthcare more generally must be weighed against the benefits of providing antiretroviral treatment to those with AIDS.

Comparison: Primary care clinics in the Free State province, South Africa. 15 clinics participating in the first phases of the national ART programme will be compared with 24 clinics which have yet to be included in the national treatment programme. The unit of analysis will be the clinic although the outcome data will be collected from individual patients.

研究设计

研究类型
Interventional
分配方式
Non Randomized
干预模型
Parallel
主要目的
Treatment
盲法
None

入排标准

性别
All
接受健康志愿者

入选标准

  • Intervention: 15 primary care clinics participating in the first phases of the national antiretroviral treatment programme
  • Control: 24 primary care clinics yet to be included in the national antiretroviral treatment programme randomly selected after stratification for health district and ranking of clinic size.
  • All patients attending tuberculosis and childhood immunization programmes at the above 39 clinics one year before and one year after antiretroviral treatment services commenced in these facilities.

排除标准

  • Clinics earmarked for the second year of the rollout of the antiretroviral treatment programme.

结局指标

主要结局

Measles immunization completed by 18 months

TB case detection

TB treatment completion

次要结局

  • TB cure rate
  • TB mortality rate
  • TB treatment failure rate
  • TB treatment interruption rate
  • Proportion of TB cases that smear positive

研究者

申办方类型
Other

研究点 (2)

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