Immunometabolic and Neuromuscular Markers of Vitality Capacity : SENIOR Protocol
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Aging
- Sponsor
- Centre Hospitalier Universitaire de Nice
- Enrollment
- 40
- Locations
- 1
- Primary Endpoint
- Difference of T cell metabolism between active and inactive participants
- Status
- Recruiting
- Last Updated
- last year
Overview
Brief Summary
The distinction between healthy and pathological ageing has given rise to the vitality capacity concept. Underlying the physiological aspect of ageing, vitality capacity is reflected in the neuromuscular function, metabolism, and immune and stress response. The three domains seem to deteriorate with age, except among individuals who have maintained physical activity throughout their lives. Furthermore, immune cells, particularly T lymphocytes, appear to play a key role in each dimension of vitality capacity, as well as in the mice ageing pathway. Investigators sought to determine the effect of lifelong physical activity on vitality capacity, and especially on T cell metabolism.
In this optic, fourty healthy participants over the age of 55 will be allocated to two groups: 20 who have maintained physical activity for the past 30 years, and 20 who have not. Each participant's vitality capacity will be deeply tested and compared to their physical activity background.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Men and women \> 55 years old
- •Participants who are non-smokers or have been weaned for more than 3 years
- •Menopausal women (confirmed for at least 6 months)
- •Participants affiliated to the social security system
- •Signature of informed consent
- •Inclusion Criteria for the active population:
- •Any person with structured aerobic physical activity (mainly involving cardiorespiratory function) on at least 3 days/week over the last 30 years without an interruption of more than 1 week in the 3 months preceding the study and without an interruption of more than 12 consecutive months over the last 30 years, as assessed by an interview conducted by an investigator specialising in physical activity;
- •have a level of physical activity that meets the recommendations for physical activity in terms of the duration and intensity of weekly cardiorespiratory effort (WHO, 2020; ANSES, 2016) according to the criteria assessed by the GPAQ: at least 150 to 300 minutes per week of moderate-intensity aerobic activity (e.g., 5 days of moderate intensity activity of at least 30 minutes/day) or at least 75 to 150 minutes of sustained intensity endurance activity (e.g., 3 days of sustained activity of 25 minutes/day); or an equivalent combination of moderate and sustained intensity activities throughout the week.
- •Inclusion criteria for the inactive population :
- •Any person who does not meet the criteria for inclusion in the 'active' population defined above;
Exclusion Criteria
- •withdraw of consent
Outcomes
Primary Outcomes
Difference of T cell metabolism between active and inactive participants
Time Frame: at day 0
On the bloodwithdraw, level of T cells metabolism will be measured by RNA sequencing
Secondary Outcomes
- WHOQOLD-OLD Questionnaire(at day 0)
- Capacity vitality(at day 0 and 14)
- Neuromuscular parameters(at day 0 and 14)