Perioperative techniques for low grade glioma patients: validation of Diffusion Tensor Imaging tractography with subcortical stimulation and prediction of postoperative functional outcome with Resting State Functional Connectivity - fMRI and DTI for low grade glioma surgery

niversitair Medisch Centrum Utrecht0 个研究点目标入组 77 人开始时间: 待定最近更新: 2024年5月6日

适应症

试验速览

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•A) Inclusion criteria Patients with LGG:;1. Candidate for surgical removal of the brain lesion
•2. Brain tumour in/near motor or language cortex;B)Inclusion criteria for healthy volunteers:;1. 25-70 years
•2. Ability to perform the fMRI tasks

•A) Exclusion criteria Patients with LGG:;1. MRI-incompatible metal objects in or around the body (braces, pacemaker, metal fragments, surgical clips)
•2. Significant cognitive deficits; non ability to perform the fMRI tasks
•3. History of neurological or psychiatric illness, not related to the brain lesion ;B) Exclusion criteria Healthy volunteers:;1. Metal objects in or around the body (braces, pacemaker, metal fragments, surgical clips)
•2. History of neurological or psychiatric illness
•3. Cerebral abnormalities on screening MRI
•4. Pregnancy as determined with a urine pregnancy test before functional MRI scanning (standard procedure for healthy volunteers at the UMC Utrecht)

发起方

niversitair Medisch Centrum Utrecht