Perioperative techniques for low grade glioma patients: validation of Diffusion Tensor Imaging tractography with subcortical stimulation and prediction of postoperative functional outcome with Resting State Functional Connectivity
- Conditions
- low grade gliomas10029211
- Registration Number
- NL-OMON33478
- Lead Sponsor
- niversitair Medisch Centrum Utrecht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 77
A) Inclusion criteria Patients with LGG:;1. Candidate for surgical removal of the brain lesion
2. Brain tumour in/near motor or language cortex;B)Inclusion criteria for healthy volunteers:;1. 25-70 years
2. Ability to perform the fMRI tasks
A) Exclusion criteria Patients with LGG:;1. MRI-incompatible metal objects in or around the body (braces, pacemaker, metal fragments, surgical clips)
2. Significant cognitive deficits; non ability to perform the fMRI tasks
3. History of neurological or psychiatric illness, not related to the brain lesion ;B) Exclusion criteria Healthy volunteers:;1. Metal objects in or around the body (braces, pacemaker, metal fragments, surgical clips)
2. History of neurological or psychiatric illness
3. Cerebral abnormalities on screening MRI
4. Pregnancy as determined with a urine pregnancy test before functional MRI scanning (standard procedure for healthy volunteers at the UMC Utrecht)
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method