Investigation of the auditory pathway in asymmetric hearing impaired patients with fMRI and comparison to [18F]FDG-PET images

Not Applicable

• Conditions: H90.1; H90.2; Conductive hearing loss, unilateral with unrestricted hearing on the contralateral side; Conductive hearing loss, unspecified

• Registration Number: DRKS00016018
• Lead Sponsor: HNO-Uniklinik Freiburg

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2019-06-27
• Study Completion: 2021-01-01
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 26

Inclusion Criteria

AHL patients
- Hearing ability of the poorer ear: severe hearing loss up to hearing loss bordering on deafness.
- Hearing ability of the better ear: air conduction hearing threshold in the range up to and including 4 kHz of > 30 dB HL and = 60 dB HL
- Preferred AHL patients who have received an [18F]FDG PET image due to a clinical indication with good image quality.

NH subjects
- Hearing in both ears: Air conduction hearing threshold in the 125-8000 Hz range of = 20 dB HL
- Speech intelligibility threshold in Oldenburg sentences test for S0N0 (fixed noise level of 65dB SPL and a start speech level of 65dB SPL)
- Monaural left: = -6 dB
- Monaural right: = -6 dB
- Binaural: = -6 dB

Exclusion Criteria

All Groups
- Age < 18 years and > 65 years
- Left-handers (Edinburgh Handsiness Inventory: Laterality Quotient< 60)
- relevant neurological or psychiatric concomitant disease (e.g. cognitive impairment, epilepsy, cerebrovascular disease, brain tumor, depression, etc.)
- Diseases that may be expected to lead to inadequate compliance with fMRI (e.g. back pain, severe claustrophobia, incontinence, metal implants, etc.)
- Pregnancy

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
In AHL patients, fMRT signal changes in the primary auditory cortices and inferior colliculi (regions-of-interest, ROIs) will be compared between resting and with acoustic, visual, and sensorimotor stimulation.

Secondary Outcome Measures

Name	Time	Method
- Comparison of fMRT signal changes of ROIs, primary auditory cortices and inferior colliculi, between AHL patients and age-matched NH controls<br>- In AHL patients: Comparison of fMRT signal changes in ROIs with the signal changes of cerebral glucose metabolism in ROIs in [18F]FDG-PET scans