Oxytocin Effects on Food Motivation Pathways
试验速览
- 阶段
- 早期 1 期
- 状态
- 已完成
- 入组人数
- 10
- 试验地点
- 1
- 主要终点
- Change in functional magnetic resonance imaging activation of food motivation brain regions
研究概览
简要总结
Oxytocin is a peptide hormone produced in the brain that regulates food intake. However, the mechanisms for this effect in humans is not yet clear.
In this study, the investigators will therefore examine the effect of a single dose of intranasal oxytocin (compared to placebo) on levels of appetite-regulating hormones and functional magnetic resonance imaging activation of areas of the brain involved in food motivation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Other
- 盲法
- Triple (Participant, Care Provider, Investigator)
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Age 18-45 years old
- •BMI 25-40
- •Regular breakfast eater (at least 4 times per week)
- •Stable weight within the past three months
排除标准
- •Psychiatric disease, use of psychotropic medications
- •History of eating disorder
- •History of excessive exercise within the last three months (having run more that 25 miles in any one week or having exercised more than ten hours in any one week)
- •History of diabetes mellitus
- •Active substance abuse
- •Hematocrit lower than the normal range
- •Gastrointestinal tract surgery (including gastrectomy, gastric bypass surgery, and small or large bowel resection)
- •History of cardiovascular disease (such as hypertrophic cardiomyopathy, valvular heart disease, coronary heart disease, or coronary artery spasms)
- •Untreated thyroid disease
- •Tobacco use
- •Cardiac pacemaker, surgical aneurysm clips, neurostimulator, implanted pumps, metal fragments in body/eyes, nitroglycerin patch, severe claustrophobia
研究组 & 干预措施
Placebo
Placebo 24 IU x 1
干预措施: Placebo (Drug)
Oxytocin
Oxytocin 24 IU x 1
干预措施: Oxytocin (Drug)
结局指标
主要结局
Change in functional magnetic resonance imaging activation of food motivation brain regions
时间窗: Functional magnetic resonance imaging at T60 min after oxytocin/placebo
次要结局
- Change in hormone levels (cholecystokinin, glucagon-like peptide-1)(Blood draws at T0, T30, T60, T120 min after oxytocin/placebo)
研究者
Elizabeth Austen Lawson
Assistant Professor of Medicine, Harvard Medical School
Massachusetts General Hospital