A Prospective, Open Large Cohort Study of Intraductal Papillary Mucinous Neoplasm (IPMN) of the Pancreas
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 5,000
- 试验地点
- 1
- 主要终点
- The accuracy of IPMN malignant transformation
研究概览
简要总结
This is a prospective, open large cohort study to explore biomarkers for detecting early carcinogenesis of IPMN.
详细描述
This prospective study was designed to explore biomarkers for detecting early carcinogenesis of IPMN. This study intends to prospectively and continuously enroll IPMN patients, and regularly collect biological samples including blood, urine, feces and saliva. We aimed to detect biomarkers which can predict the carcinogenesis of IPMN by multi-omics. The primary endpoint is the predictive accuracy of biomarkers for IPMN malignant transformation. The probability of IPMN malignant transformation , rates of surgical resection and survival after surgery are secondary endpoints.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 0 Years 至 90 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •clinically diagnosed as IPMN;
- •without other malignant tumor;
- •agree to sign informed consent.
排除标准
- •with mental disorders which can affect cognition and cooperation;
- •with serious blood diseases or taking drugs that can affect peripheral blood
结局指标
主要结局
The accuracy of IPMN malignant transformation
时间窗: Up to 10 years
次要结局
- rates of surgical resection(Up to 10 years)
- the probability of IPMN malignant transformation(Up to 10 years)
- survival after surgery(Up to 10-15 years)
研究者
TingBo Liang
The chairman of the First Affiliated Hospital of Zhejiang
Zhejiang University