Effect of increased propionate in the colon on appetite and glucose homeostasis

Imperial College London (UK)0 个研究点目标入组 12 人开始时间: 2014年9月26日最近更新: 2021年5月24日

试验速览

•1. Healthy volunteers aged 18-65
•2. Male or female
•3. Body mass index (weight in kg divided by height in metre squared) of 25-40 kg/m2
•Added 24/01/2018:
•1. Male or female aged 18-65 years
•2. Body mass index (weight in kg divided by height in metre squared) of BMI of 20-40 kg/m2
•3. Histological confirmation of NAFLD in previous 5 years.
•4. Controlled blood glucose levels (HbA1c <48 mmol/mol)

•Study 1 and Study 2:
•1. Weight change of more than 3kg in the preceding 3 months
•2. Current smokers
•3. Substance abuse
•4. Excess alcohol intake
•5. Pregnancy
•6. Diabetes
•7. Cardiovascular disease
•9. Gastrointestinal disease e.g. inflammatory bowel disease or irritable bowel syndrome
•10. Kidney disease
•11. Liver disease
•12. Pancreatitis
•13. Use of medications including: antiinflammatory drugs or steroids, androgens, phenytoin, erythromycin or thyroid hormones
•Study 2 has the additional exclusion criteria:
•14.? Metallic or magnetic implants such as pacemakers
•?15. Claustrophobia

发起方

Imperial College London (UK)