Prospective randomised multicentre trial investigating liver preservation with Histidine-Tryptophan-Ketoglutarate (HTK) by simple aortic perfusion in comparison to aortic perfusion plus ex situ arterial flushing

Not Applicable

Completed

• Conditions: iver transplantation after preservation in brain-death organ donors; Surgery; Transplantation surgery

• Registration Number: ISRCTN78500982
• Lead Sponsor: Johannes Gutenberg University of Mainz (Germany)

Brief Summary

2017 Results article in https://pubmed.ncbi.nlm.nih.gov/28706986/ (added 29/10/2021)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2007-08-10
• Study Completion: 2009-10-31
• Last Update Posted: 8 November 2021

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 242

Inclusion Criteria

For the graft:
1. Liver graft retrieved in the Central Region of the German Foundation for Organ Transplantion (Region Mitte der Deutschen Stiftung Organtransplantation [DSO])
2. Donor 18 - 80 years
3. Graft allocation to a participating centre

For the recipient
1. Informed consent
2. Age 18 - 80 years
3. Standard criteria for liver transplantation (e.g. liver dysfunction because of cirrhosis, carcinoma)

Exclusion Criteria

For the graft:
1. Liver cirrhosis
2. Liver intoxication
3. Liver dysfunction
4. Liver trauma
5. Graft not transplantable (decision according to Standard Operating Procedures [SOP])
6. Liver split

For the recipient:
1. Standard criteria for liver transplantation

Study & Design

• Study Type: Interventional
• Study Design: Not specified