Low Level Laser Versus Polarized Light in the Treatment of Acne Vulgaris

Not Applicable

Completed

• Conditions: Low Level Laser Therapy; Acne Vulgaris

• Registration Number: NCT06867276
• Lead Sponsor: Cairo University

Brief Summary

The present study is designed to compare clinically the therapeutic applications between low level laser therapy (excimer laser) and non-laser polarized light (Bioptron prol) in the treatment of Acne vulgaris.

Detailed Description

Traditional acne treatment often involves topical application, which can cause skin irritation and dryness, and oral antibiotic therapy, which is limited by antibiotic resistance. Newer procedures like laser and light-based therapies offer alternative treatments for patients who struggle with adherence or experience side effects or treatment failure. This study aims to compare the therapeutic application of laser and light therapies as an alternative to traditional acne treatments.

Study Timeline

• Study Start: 2024-01-15
• Primary Completion: 2024-11-22
• Study Completion: 2024-12-22
• Study First Submitted: 2025-02-28
• Status Verified: 2025-03
• Study First Submitted QC: 2025-03-07
• Last Update Submitted: 2025-03-07
• Study First Posted: 2025-03-10
• Last Update Posted: 2025-03-10

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

1. Female and male patients.
2. Age range between 18 and 25 years.
3. All patients will sign their informed consent to participate in the research procedure and to publish the data.
4. Definite clinical diagnosis of mild to moderate inflammatory lesions of facial Acne vulgaris (open and closed comedones, papules, pustules, and nodules) on the face that has been going on for at least 1 month.

Exclusion Criteria

1. Patient's unwillingness to continue cooperation in the study
2. Photosensitive skin.
3. Pregnancy and breast feeding.
4. Women who use hormonal contraceptives.
5. Patients who had used oral retinoids or any other treatment for acne in the last month.
6. Patients with severe nodulocystic acne

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
assessment of change of Global Assessment Scale	At baseline and after 4 weeks	For the study, we recruited males and females with mild to moderate acne according to the Investigator's Global Assessment (IGA) scale, where the severity of acne and the type of lesions was assigned to it.; the scoring ranges from 0 to 4. Zero indicates clear skin with no inflammatory and non- inflammatory lesions, while 4 indicates severe lesion with Many comedones and inflammatory lesions, ≤ several nodules and cysts

Secondary Outcome Measures

Name	Time	Method
assesment of change of digital facial photographs	At baseline and after 4 weeks	Digital Facial photographs, included in the photographic documentation, were taken by (Nikon Camera), before the procedure and four weeks after the end of the whole therapy.; Digital facial photographs will be taken for each patient at the base line and end of the fourth week to track the development of acne lesions and evaluate treatment effectiveness, using the same method for each patient.

Trial Locations

Locations (1)

out-patient clinic, faculty of physical therapy, Cairo university; 🇪🇬 Cairo, Egypt