Evaluation of Peripheral Neutrophils in Patients With Antisynthetase Syndrome
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Global severity
研究概览
简要总结
Antisynthetase syndrome (AS) is a rare overlapping myositis characterized by cellular and humoral autoimmune responses directed against aminoacyl-tRNA synthetases. A pathogenic role of neutrophils was described during inflammatory myopathies, with increased netosis correlated with disease activity and muscle damage. Higher number of alveolar neutrophils was observed in patients with rapidly progressive forms of interstitial lung disease.
Peripheral neutrophils could represent a simple biomarker of severity and activity in patients with antisynthetase syndrome.
The main objective is to compare circulating neutrophils between severe and non severe patients with antisynthetase syndrome. Secondary objectives are: 1) to evaluate correlation between circulating neutrophils and organ-specific severity, 2) to compare circulating neutrophils at time of diagnosis and circulating neutrophils after 6 months of treatment in patients with antisynthetase syndrome.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with antisyntheatse syndrome according to Solomon criteria
排除标准
- 未提供
结局指标
主要结局
Global severity
时间窗: at diagnosis (Day 0)
composite criteria of global severity: severe interstitial lung disease (ILD) and/or severe muscular disease
Number of circulating neutrophils
时间窗: at diagnosis (Day 0)
circulating neutrophils values (number of cells/mm3)
次要结局
- ILD severity(at diagnosis (Day 0))
- Muscular severity(at diagnosis (Day 0))
- Circulating neutrophils change over time(at 6 months of follow-up)
研究者
Paul DECKER, MD
Principal Investigator
Central Hospital, Nancy, France