Comparison of The Efficacy And Side Effects of Combined Doses of Dexmedetomidine And Propofol With Isoflurane And Nitrosoxide as a General Anesthetic Preservative in Orthopedic Surgeries

Phase 3

Recruiting

Conditions: Depth of anesthesia.
Other medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure

Registration Number: IRCT20210904052371N3

Lead Sponsor: Mazandaran University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 90

Inclusion Criteria

The patient's desire to participate in the study and gain informed consent
Candidate for non-emergency orthopedic surgery under general anesthesia
Age between 18-60 years
Class 1 and 2 Anesthesia (ASA)
Patients who do not have complications such as hypotension, hypertension, bradycardia, pneumothorax, air embolism and decreased arterial oxygen saturation, which is a possible side effect of anesthetics

Exclusion Criteria

Emergency surgery
Known allergies to the drugs used in the present study
Operation longer than 5 hours
Patients during the intervention if acute complications such as hypotension, hypertension, bradycardia, pneumothorax, air embolism and a decrease in arterial oxygen saturation.

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Time to wake up from anesthesia. Timepoint: From the moment of closing the anesthetic (inhaled or intravenous) to the moment of waking the patient if the patient is able to obey instructions and communicate. Method of measurement: Visual Analogue Scale.

Secondary Outcome Measures

Name	Time	Method
Depth of anesthesia. Timepoint: Immediately before and after induction (before starting maintenance dose), while receiving maintenance dose, when discontinuing anesthesia, moment of awakening from anesthesia, end of recovery. Method of measurement: brain function assessment.