NCT01384656已完成4 期
Effect of Glucose-insulin-potassium Solution on Myocardial Protection During Off-pump Coronary Bypass Surgery in Patients With Acute Coronary Syndrome
适应症
干预措施
相关药物
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 66
- 试验地点
- 1
- 主要终点
- CK-MB(creatinine kinase-MB) mass
研究概览
简要总结
Patients undergoing multivessel off-pump coronary bypass surgery (OPCAB) inevitably experience cumulative ischemia-reperfusion injury at myocardium. Glucose-insulin-potassium (GIK) is a potentially useful adjunct to myocardial protection. This study was designed to evaluate the effects of GIK infusion on myocardium in patients undergoing OPCAB. Patients undergoing OPCAB with acute coronary syndrome are randomly assigned to GIK or Control group. The trial is double-blind and conducted at a single center.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients undergoing isolated OPCAB.
- •Age: 20~75.
排除标准
- •Emergency operation.
- •Patients with MR ≥
- •Patients with IDDM.
- •Patients with random sugar ≥ 250 mg/dL.
- •Patients with serum creatinine ≥ 2.0 mg/dL.
- •Patients with acute myocardial infarction within 1 week of surgery
研究组 & 干预措施
GIK group
Experimental
干预措施: GIK solution (Drug)
Control group
Placebo Comparator
干预措施: GIK solution (Drug)
结局指标
主要结局
CK-MB(creatinine kinase-MB) mass
时间窗: 12 hours after the surgery
Comparison of cardiac enzyme elevation after surgery between GIK and Control group.
次要结局
未报告次要终点
研究者
研究点 (1)
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