Genetic Polymorphisms Associated With Cigarette Smoking and Risk of Graves' Disease

Completed

• Conditions: Graves' Disease

• Registration Number: NCT00505011
• Lead Sponsor: University of Campinas, Brazil

Brief Summary

Cigarette smoking is a well-recognized risk factor of Graves' disease and, particularly, Graves' ophthalmopathy. Hence, germline polymorphisms of detoxification genes and genes belonging to the major DNA repair/apoptosis pathways might have an important role in disease susceptibility. In addition, as some of these genes are regulated by thyroid hormones, they could affect the outcome of these patients. Our objective was to assess the influence of the GST, CYP and TP53 gene polymorphisms in the risk of Graves' disease and its outcome.

Detailed Description

Although the role of many polymorphisms of genes related to toxins' metabolism has been extensively investigated regarding the susceptibility to thyroid cancer, their influence in thyroid autoimmune diseases risk is still largely unknown. Hence, this study was designed to assess the influence of GSTT1, GSTM1, GSTP1, CYP1A1 and 72TP53 polymorphic inheritance on the susceptibility to Graves' disease and to its response to the treatment.

Study Timeline

• Study Start: 1998-02
• Study Completion: 2007-02
• Status Verified: 2007-07
• Study First Submitted: 2007-07-18
• Study First Submitted QC: 2007-07-19
• Last Update Submitted: 2007-07-19
• Study First Posted: 2007-07-20
• Last Update Posted: 2007-07-20

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 1998

Inclusion Criteria

• Graves' disease patients

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified