In women with threatened miscarriage, does progesterone supplementation increase the likelihood of live birth?

Phase 3

Completed

• Conditions: Threatened Miscarriage; Reproductive Health and Childbirth - Fertility including in vitro fertilisation

• Registration Number: ACTRN12611000405910
• Lead Sponsor: Dr Luke McLindon

Brief Summary

In women with threatened miscarriage as apparent from vaginal bleeding under 10 weeks, 400mg vaginal progesterone nightly from the onset of bleeding until 12 weeks did not improve live birth rates when compared with placebo.

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2011-04-19
• Study Completion: 2019-03-29
• Last Update Posted: 21 December 2021

Recruitment & Eligibility

• Status: Completed
• Sex: Female
• Target Recruitment: 279

Inclusion Criteria

Threatened miscarriage
Live intra-uterine pregnancy
Gestation less than 10 weeks + 0 days

Exclusion Criteria

Pregnancy as a result of Assisted Reproductive Technologies

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
ive Birth[Completion of index pregnancy]

Secondary Outcome Measures

Name	Time	Method
Complete miscarriage[Completion of index pregnacy];Gestation at birth[Completion of index pregnancy];Birth weight[Completion of index pregnancy];Congenital anomaly[Completion of index pregnancy];Antepartum haemorrhage[Completion of index pregnancy]