Targeting the Carotid Bodies to Reduce Disease Risk Along the Diabetes Continuum
Not Applicable
Completed
- Conditions
- Type 2 Diabetes
- Registration Number
- NCT05219994
- Lead Sponsor
- University of Missouri-Columbia
- Brief Summary
Our overall goal is to advance our understanding of the contribution of the carotid body chemoreceptors in glucose regulation and the development of type 2 diabetes.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 22
Inclusion Criteria
- healthy,
- type 2 diabetes
- BMI 18-40 kg/m2,
- non-pregnant,
- non-breastfeeding,
- non-nicotine users.
Exclusion Criteria
- cardiovascular disease including myocardial infarction, heart failure, coronary artery disease, stroke;
- renal or hepatic diseases;
- active cancer;
- autoimmune diseases;
- immunosuppressant therapy;
- excessive alcohol consumption (>14 drinks/week);
- current nicotine use;
- foot ulcers;
- diabetic neuropathy;
- medication directly influencing sympathetic nervous system activity
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Primary Outcome Measures
Name Time Method Insulin change in response to OGTT 2 hours post glucose ingestion Glucose change in response to OGTT 2 hours post glucose ingestion
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
University of Missouri
🇺🇸Columbia, Missouri, United States
University of Missouri🇺🇸Columbia, Missouri, United States