Transpulmonary Pressure Under Conditions of Increased Intra-abdominal Pressure From Pneumoperitoneum and Steep Trendelenburg
试验速览
- 阶段
- 不适用
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Incidence of postoperative acute complications
研究概览
简要总结
Study aims to prospectively evaluate if the pressures normally applied during mechanical ventilation in laparoscopic surgery induce stress on the pulmonary wall. To do this is used measure the variation of esophageal pressure, as indirect index of the pleural pressure and therefore of the transpulmonary pressure, in response to changes in airway pressures in a group of patients undergoing robotic assisted radical prostatectomy or videolaparoscopy.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •ASA (american society of anesthesiologists) score ≤ III
- •Patients underwent laparoscopic prostatectomy
排除标准
- •BMI (body mass index) ≥ 30
- •Impossibility to insert nasogastric tube
- •Anatomic rib cage alterations
结局指标
主要结局
Incidence of postoperative acute complications
时间窗: 24 hours
Evaluation of pulmonary alterations using pre and postoperative ultrasonographic visualization
Dosage of inflammatory mediators
时间窗: 24 hours
Dosage of metalloproteinase and interleukin 8 in bronchoaspiration
次要结局
未报告次要终点
研究者
Ester Forastiere
Head of Department of Anaestesiology and Critical Care
Regina Elena Cancer Institute