Transpulmonary Pressure Under Conditions of Increased Intra-abdominal Pressure From Pneumoperitoneum and Steep Trendelenburg
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Ventilator-Induced Lung Injury
- Sponsor
- Regina Elena Cancer Institute
- Enrollment
- 20
- Locations
- 1
- Primary Endpoint
- Incidence of postoperative acute complications
- Last Updated
- 6 years ago
Overview
Brief Summary
Study aims to prospectively evaluate if the pressures normally applied during mechanical ventilation in laparoscopic surgery induce stress on the pulmonary wall. To do this is used measure the variation of esophageal pressure, as indirect index of the pleural pressure and therefore of the transpulmonary pressure, in response to changes in airway pressures in a group of patients undergoing robotic assisted radical prostatectomy or videolaparoscopy.
Investigators
Ester Forastiere
Head of Department of Anaestesiology and Critical Care
Regina Elena Cancer Institute
Eligibility Criteria
Inclusion Criteria
- •ASA (american society of anesthesiologists) score ≤ III
- •Patients underwent laparoscopic prostatectomy
Exclusion Criteria
- •BMI (body mass index) ≥ 30
- •Impossibility to insert nasogastric tube
- •Anatomic rib cage alterations
Outcomes
Primary Outcomes
Incidence of postoperative acute complications
Time Frame: 24 hours
Evaluation of pulmonary alterations using pre and postoperative ultrasonographic visualization
Dosage of inflammatory mediators
Time Frame: 24 hours
Dosage of metalloproteinase and interleukin 8 in bronchoaspiration