The age-dependent influence of the microbiome, metabolome and oral health on the outcome of assisted reproductive medical treatment (AROMA)

Recruiting

• Conditions: Z31; Procreative management

• Registration Number: DRKS00034015
• Lead Sponsor: niveristitätsklinikum Heidelberg

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2024-06-17
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Female
• Target Recruitment: 1000

Inclusion Criteria

• Capacity to consent
- Signed declaration of consent and consent to the
data protection regulations
- No contraindication for clinical-dental probing to determine the periodontal status (Z.n. endocarditis, immunosuppression, Z.n. radiotherapy in the head and neck area)
- No known general diseases that could have an influence on the oral microbiome

Exclusion Criteria

-Existing pregnancy
- Immunosuppressive therapy
- Taking medication that can have an effect on (gingival) inflammation
- Presence of a serious general illness including illnesses with a high risk of endocarditis, immunosuppression and existing infectious diseases (e.g. HIV)
- Non-compliance with the study-related requirements (oral hygiene in the last 12 hours before sample collection)
- vaginal infections
- acute infections

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The target criteria are differences in the oral and vaginal microbiome and metabolome in women with successful ART (pregnancy) compared to unsuccessful ART. <br>14 days after follicular puncture, ßHCG is determined from the blood. Pregnancy exists if a positive cardiac action is detected on ultrasound.

Secondary Outcome Measures

Name	Time	Method
ive births only in direct connection with the ART cycle under investigation